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ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms

Metal-Organic Frameworks (MOFs) offer new ideas for the design of antibacterial materials because of their antibacterial properties, high porosity and specific surface area, low toxicity and good biocompatibility compared with other nanomaterials. Herein, a novel antimicrobial nanomaterial, MIL-101(...

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Autores principales: Zheng, Huiying, Zhong, Biying, Wang, Qiaowen, Li, Xi, Chen, Jiehan, Liu, Li, Liu, Tiantian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418459/
https://www.ncbi.nlm.nih.gov/pubmed/37569611
http://dx.doi.org/10.3390/ijms241512238
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author Zheng, Huiying
Zhong, Biying
Wang, Qiaowen
Li, Xi
Chen, Jiehan
Liu, Li
Liu, Tiantian
author_facet Zheng, Huiying
Zhong, Biying
Wang, Qiaowen
Li, Xi
Chen, Jiehan
Liu, Li
Liu, Tiantian
author_sort Zheng, Huiying
collection PubMed
description Metal-Organic Frameworks (MOFs) offer new ideas for the design of antibacterial materials because of their antibacterial properties, high porosity and specific surface area, low toxicity and good biocompatibility compared with other nanomaterials. Herein, a novel antimicrobial nanomaterial, MIL-101(Fe)@ZnO, has been synthesized by hydrothermal synthesis and characterized by FTIR, UV-vis, ICP-OES, XRD, SEM, EDS and BET to show that the zinc ions are doped into the crystal lattice of MIL-101(Fe) to form a Fe-Zn bimetallic structure. MIL-101(Fe)@ZnO was found to be effective against a wide range of antibacterial materials including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Acinetobacter junii and Staphylococcus epidermidis. It has a significant antibacterial effect, weak cytotoxicity, high safety performance and good biocompatibility. Meanwhile, MIL-101(Fe)@ZnO was able to achieve antibacterial effects by causing cells to produce ROS, disrupting the cell membrane structure, and causing protein leakage and lipid preoxidation mechanisms. In conclusion, MIL-101(Fe)@ZnO is an easy-to-prepare antimicrobial nanomaterial with broad-spectrum bactericidal activity and low toxicity.
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spelling pubmed-104184592023-08-12 ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms Zheng, Huiying Zhong, Biying Wang, Qiaowen Li, Xi Chen, Jiehan Liu, Li Liu, Tiantian Int J Mol Sci Article Metal-Organic Frameworks (MOFs) offer new ideas for the design of antibacterial materials because of their antibacterial properties, high porosity and specific surface area, low toxicity and good biocompatibility compared with other nanomaterials. Herein, a novel antimicrobial nanomaterial, MIL-101(Fe)@ZnO, has been synthesized by hydrothermal synthesis and characterized by FTIR, UV-vis, ICP-OES, XRD, SEM, EDS and BET to show that the zinc ions are doped into the crystal lattice of MIL-101(Fe) to form a Fe-Zn bimetallic structure. MIL-101(Fe)@ZnO was found to be effective against a wide range of antibacterial materials including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Acinetobacter junii and Staphylococcus epidermidis. It has a significant antibacterial effect, weak cytotoxicity, high safety performance and good biocompatibility. Meanwhile, MIL-101(Fe)@ZnO was able to achieve antibacterial effects by causing cells to produce ROS, disrupting the cell membrane structure, and causing protein leakage and lipid preoxidation mechanisms. In conclusion, MIL-101(Fe)@ZnO is an easy-to-prepare antimicrobial nanomaterial with broad-spectrum bactericidal activity and low toxicity. MDPI 2023-07-31 /pmc/articles/PMC10418459/ /pubmed/37569611 http://dx.doi.org/10.3390/ijms241512238 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zheng, Huiying
Zhong, Biying
Wang, Qiaowen
Li, Xi
Chen, Jiehan
Liu, Li
Liu, Tiantian
ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title_full ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title_fullStr ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title_full_unstemmed ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title_short ZnO-Doped Metal-Organic Frameworks Nanoparticles: Antibacterial Activity and Mechanisms
title_sort zno-doped metal-organic frameworks nanoparticles: antibacterial activity and mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418459/
https://www.ncbi.nlm.nih.gov/pubmed/37569611
http://dx.doi.org/10.3390/ijms241512238
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