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Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. We describe four new cases of Tako-Tsubo syndr...

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Autores principales: Napoli, Giovanni, Rubin, Martina, Cutillo, Gianni, Schito, Paride, Russo, Tommaso, Quattrini, Angelo, Filippi, Massimo, Riva, Nilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418501/
https://www.ncbi.nlm.nih.gov/pubmed/37569475
http://dx.doi.org/10.3390/ijms241512096
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author Napoli, Giovanni
Rubin, Martina
Cutillo, Gianni
Schito, Paride
Russo, Tommaso
Quattrini, Angelo
Filippi, Massimo
Riva, Nilo
author_facet Napoli, Giovanni
Rubin, Martina
Cutillo, Gianni
Schito, Paride
Russo, Tommaso
Quattrini, Angelo
Filippi, Massimo
Riva, Nilo
author_sort Napoli, Giovanni
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. We describe four new cases of Tako-Tsubo syndrome (TTS) in ALS patients with an appraisal of the literature. We present a late-stage ALS patient with prominent bulbar involvement that presented TTS during hospitalization. We then retrospectively identify three additional ALS–TTS cases reporting relevant clinical findings. TTS cardiomyopathy has been observed in different acute neurological conditions, and the co-occurrence of ALS and TTS has already been reported. Cardiovascular autonomic dysfunctions have been described in ALS, especially in the context of an advanced diseases and with bulbar involvement. Noradrenergic hyperfunction linked to sympathetic denervation and ventilatory deficits coupled in different instances with a trigger event could play a synergistic role in the development of TTS in ALS. Sympathetic hyperfunctioning and ventilatory deficits in conjunction with cardiac autonomic nerves impairment may play a role in the development of TTS in a context of ALS.
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spelling pubmed-104185012023-08-12 Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review Napoli, Giovanni Rubin, Martina Cutillo, Gianni Schito, Paride Russo, Tommaso Quattrini, Angelo Filippi, Massimo Riva, Nilo Int J Mol Sci Case Report Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. We describe four new cases of Tako-Tsubo syndrome (TTS) in ALS patients with an appraisal of the literature. We present a late-stage ALS patient with prominent bulbar involvement that presented TTS during hospitalization. We then retrospectively identify three additional ALS–TTS cases reporting relevant clinical findings. TTS cardiomyopathy has been observed in different acute neurological conditions, and the co-occurrence of ALS and TTS has already been reported. Cardiovascular autonomic dysfunctions have been described in ALS, especially in the context of an advanced diseases and with bulbar involvement. Noradrenergic hyperfunction linked to sympathetic denervation and ventilatory deficits coupled in different instances with a trigger event could play a synergistic role in the development of TTS in ALS. Sympathetic hyperfunctioning and ventilatory deficits in conjunction with cardiac autonomic nerves impairment may play a role in the development of TTS in a context of ALS. MDPI 2023-07-28 /pmc/articles/PMC10418501/ /pubmed/37569475 http://dx.doi.org/10.3390/ijms241512096 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Napoli, Giovanni
Rubin, Martina
Cutillo, Gianni
Schito, Paride
Russo, Tommaso
Quattrini, Angelo
Filippi, Massimo
Riva, Nilo
Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title_full Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title_fullStr Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title_full_unstemmed Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title_short Tako-Tsubo Syndrome in Amyotrophic Lateral Sclerosis: Single-Center Case Series and Brief Literature Review
title_sort tako-tsubo syndrome in amyotrophic lateral sclerosis: single-center case series and brief literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418501/
https://www.ncbi.nlm.nih.gov/pubmed/37569475
http://dx.doi.org/10.3390/ijms241512096
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