Differentially Expressed Genes Regulating Glutathione Metabolism, Protein-Folding, and Unfolded Protein Response in Pancreatic β-Cells in Type 2 Diabetes Mellitus

Impaired redox homeostasis in the endoplasmic reticulum (ER) may contribute to proinsulin misfolding and thus to activate the unfolded protein response (UPR) and apoptotic pathways, culminating in pancreatic β-cell loss and type 2 diabetes (T2D). The present study was designed to identify differenti...

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Detalles Bibliográficos
Autores principales: Klyosova, Elena, Azarova, Iuliia, Buikin, Stepan, Polonikov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418503/
https://www.ncbi.nlm.nih.gov/pubmed/37569434
http://dx.doi.org/10.3390/ijms241512059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418503/
https://www.ncbi.nlm.nih.gov/pubmed/37569434
http://dx.doi.org/10.3390/ijms241512059

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