Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses

Chitosan films were prepared by solvent casting using an acetic acid-based solution. The films that were developed contained 15.49% of acetic acid solution (10% v/v) and showed biocompatibility in vitro in human keratinocyte HaCaT cells and potent antiviral activity against both enveloped and non-en...

Descripción completa

Detalles Bibliográficos
Autores principales: Cano-Vicent, Alba, Tuñón-Molina, Alberto, Martí, Miguel, Serrano-Aroca, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418510/
https://www.ncbi.nlm.nih.gov/pubmed/37569404
http://dx.doi.org/10.3390/ijms241512028
_version_ 1785088282194870272
author Cano-Vicent, Alba
Tuñón-Molina, Alberto
Martí, Miguel
Serrano-Aroca, Ángel
author_facet Cano-Vicent, Alba
Tuñón-Molina, Alberto
Martí, Miguel
Serrano-Aroca, Ángel
author_sort Cano-Vicent, Alba
collection PubMed
description Chitosan films were prepared by solvent casting using an acetic acid-based solution. The films that were developed contained 15.49% of acetic acid solution (10% v/v) and showed biocompatibility in vitro in human keratinocyte HaCaT cells and potent antiviral activity against both enveloped and non-enveloped viruses. The results showed up to 99.98% and 99.92% viral inactivation against the phi 6 enveloped bacteriophage and MS2 non-enveloped bacteriophage, respectively, suggesting that this chitosan/acetic acid film is a promising material for biomedical applications that require biodegradable broad-spectrum antiviral materials.
format Online
Article
Text
id pubmed-10418510
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104185102023-08-12 Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses Cano-Vicent, Alba Tuñón-Molina, Alberto Martí, Miguel Serrano-Aroca, Ángel Int J Mol Sci Communication Chitosan films were prepared by solvent casting using an acetic acid-based solution. The films that were developed contained 15.49% of acetic acid solution (10% v/v) and showed biocompatibility in vitro in human keratinocyte HaCaT cells and potent antiviral activity against both enveloped and non-enveloped viruses. The results showed up to 99.98% and 99.92% viral inactivation against the phi 6 enveloped bacteriophage and MS2 non-enveloped bacteriophage, respectively, suggesting that this chitosan/acetic acid film is a promising material for biomedical applications that require biodegradable broad-spectrum antiviral materials. MDPI 2023-07-27 /pmc/articles/PMC10418510/ /pubmed/37569404 http://dx.doi.org/10.3390/ijms241512028 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Cano-Vicent, Alba
Tuñón-Molina, Alberto
Martí, Miguel
Serrano-Aroca, Ángel
Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title_full Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title_fullStr Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title_full_unstemmed Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title_short Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses
title_sort biocompatible chitosan films containing acetic acid manifested potent antiviral activity against enveloped and non-enveloped viruses
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418510/
https://www.ncbi.nlm.nih.gov/pubmed/37569404
http://dx.doi.org/10.3390/ijms241512028
work_keys_str_mv AT canovicentalba biocompatiblechitosanfilmscontainingaceticacidmanifestedpotentantiviralactivityagainstenvelopedandnonenvelopedviruses
AT tunonmolinaalberto biocompatiblechitosanfilmscontainingaceticacidmanifestedpotentantiviralactivityagainstenvelopedandnonenvelopedviruses
AT martimiguel biocompatiblechitosanfilmscontainingaceticacidmanifestedpotentantiviralactivityagainstenvelopedandnonenvelopedviruses
AT serranoarocaangel biocompatiblechitosanfilmscontainingaceticacidmanifestedpotentantiviralactivityagainstenvelopedandnonenvelopedviruses

Ejemplares similares