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Antigenic diversity and dengue disease risk

Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibo...

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Autores principales: Wang, Lin, Huang, Angkana T., Katzelnick, Leah C., Lefrancq, Noémie, Escoto, Ana Coello, Duret, Loréna, Chowdhury, Nayeem, Jarman, Richard, Conte, Matthew A., Berry, Irina Maljkovic, Fernandez, Stefan, Klungthong, Chonticha, Thaisomboonsuk, Butsaya, Suntarattiwong, Piyarat, Vandepitte, Warunee, Whitehead, Stephen, Cauchemez, Simon, Cummings, Derek A.T., Salje, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418532/
https://www.ncbi.nlm.nih.gov/pubmed/37577717
http://dx.doi.org/10.21203/rs.3.rs-3214507/v1
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author Wang, Lin
Huang, Angkana T.
Katzelnick, Leah C.
Lefrancq, Noémie
Escoto, Ana Coello
Duret, Loréna
Chowdhury, Nayeem
Jarman, Richard
Conte, Matthew A.
Berry, Irina Maljkovic
Fernandez, Stefan
Klungthong, Chonticha
Thaisomboonsuk, Butsaya
Suntarattiwong, Piyarat
Vandepitte, Warunee
Whitehead, Stephen
Cauchemez, Simon
Cummings, Derek A.T.
Salje, Henrik
author_facet Wang, Lin
Huang, Angkana T.
Katzelnick, Leah C.
Lefrancq, Noémie
Escoto, Ana Coello
Duret, Loréna
Chowdhury, Nayeem
Jarman, Richard
Conte, Matthew A.
Berry, Irina Maljkovic
Fernandez, Stefan
Klungthong, Chonticha
Thaisomboonsuk, Butsaya
Suntarattiwong, Piyarat
Vandepitte, Warunee
Whitehead, Stephen
Cauchemez, Simon
Cummings, Derek A.T.
Salje, Henrik
author_sort Wang, Lin
collection PubMed
description Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibody-dependent enhancement. However, it remains a mystery whether the antigenic distance between an individual’s first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalisations across years. Here we develop an inferential framework that combines detailed antigenic and genetic characterisation of viruses, and hospitalised cases from 21 years of surveillance in Bangkok, Thailand to identify the role of the antigenic profile of circulating viruses in determining disease risk. We find that the risk of hospitalisation depends on both the specific order of infecting serotypes and the antigenic distance between an individual’s primary and secondary infections, with risk maximised at intermediate antigenic distances. These findings suggest immune imprinting helps determine dengue disease risk, and provides a pathway to monitor the changing risk profile of populations and to quantifying risk profiles of candidate vaccines.
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spelling pubmed-104185322023-08-12 Antigenic diversity and dengue disease risk Wang, Lin Huang, Angkana T. Katzelnick, Leah C. Lefrancq, Noémie Escoto, Ana Coello Duret, Loréna Chowdhury, Nayeem Jarman, Richard Conte, Matthew A. Berry, Irina Maljkovic Fernandez, Stefan Klungthong, Chonticha Thaisomboonsuk, Butsaya Suntarattiwong, Piyarat Vandepitte, Warunee Whitehead, Stephen Cauchemez, Simon Cummings, Derek A.T. Salje, Henrik Res Sq Article Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibody-dependent enhancement. However, it remains a mystery whether the antigenic distance between an individual’s first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalisations across years. Here we develop an inferential framework that combines detailed antigenic and genetic characterisation of viruses, and hospitalised cases from 21 years of surveillance in Bangkok, Thailand to identify the role of the antigenic profile of circulating viruses in determining disease risk. We find that the risk of hospitalisation depends on both the specific order of infecting serotypes and the antigenic distance between an individual’s primary and secondary infections, with risk maximised at intermediate antigenic distances. These findings suggest immune imprinting helps determine dengue disease risk, and provides a pathway to monitor the changing risk profile of populations and to quantifying risk profiles of candidate vaccines. American Journal Experts 2023-08-02 /pmc/articles/PMC10418532/ /pubmed/37577717 http://dx.doi.org/10.21203/rs.3.rs-3214507/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Wang, Lin
Huang, Angkana T.
Katzelnick, Leah C.
Lefrancq, Noémie
Escoto, Ana Coello
Duret, Loréna
Chowdhury, Nayeem
Jarman, Richard
Conte, Matthew A.
Berry, Irina Maljkovic
Fernandez, Stefan
Klungthong, Chonticha
Thaisomboonsuk, Butsaya
Suntarattiwong, Piyarat
Vandepitte, Warunee
Whitehead, Stephen
Cauchemez, Simon
Cummings, Derek A.T.
Salje, Henrik
Antigenic diversity and dengue disease risk
title Antigenic diversity and dengue disease risk
title_full Antigenic diversity and dengue disease risk
title_fullStr Antigenic diversity and dengue disease risk
title_full_unstemmed Antigenic diversity and dengue disease risk
title_short Antigenic diversity and dengue disease risk
title_sort antigenic diversity and dengue disease risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418532/
https://www.ncbi.nlm.nih.gov/pubmed/37577717
http://dx.doi.org/10.21203/rs.3.rs-3214507/v1
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