Cargando…
Antigenic diversity and dengue disease risk
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibo...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418532/ https://www.ncbi.nlm.nih.gov/pubmed/37577717 http://dx.doi.org/10.21203/rs.3.rs-3214507/v1 |
_version_ | 1785088286567432192 |
---|---|
author | Wang, Lin Huang, Angkana T. Katzelnick, Leah C. Lefrancq, Noémie Escoto, Ana Coello Duret, Loréna Chowdhury, Nayeem Jarman, Richard Conte, Matthew A. Berry, Irina Maljkovic Fernandez, Stefan Klungthong, Chonticha Thaisomboonsuk, Butsaya Suntarattiwong, Piyarat Vandepitte, Warunee Whitehead, Stephen Cauchemez, Simon Cummings, Derek A.T. Salje, Henrik |
author_facet | Wang, Lin Huang, Angkana T. Katzelnick, Leah C. Lefrancq, Noémie Escoto, Ana Coello Duret, Loréna Chowdhury, Nayeem Jarman, Richard Conte, Matthew A. Berry, Irina Maljkovic Fernandez, Stefan Klungthong, Chonticha Thaisomboonsuk, Butsaya Suntarattiwong, Piyarat Vandepitte, Warunee Whitehead, Stephen Cauchemez, Simon Cummings, Derek A.T. Salje, Henrik |
author_sort | Wang, Lin |
collection | PubMed |
description | Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibody-dependent enhancement. However, it remains a mystery whether the antigenic distance between an individual’s first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalisations across years. Here we develop an inferential framework that combines detailed antigenic and genetic characterisation of viruses, and hospitalised cases from 21 years of surveillance in Bangkok, Thailand to identify the role of the antigenic profile of circulating viruses in determining disease risk. We find that the risk of hospitalisation depends on both the specific order of infecting serotypes and the antigenic distance between an individual’s primary and secondary infections, with risk maximised at intermediate antigenic distances. These findings suggest immune imprinting helps determine dengue disease risk, and provides a pathway to monitor the changing risk profile of populations and to quantifying risk profiles of candidate vaccines. |
format | Online Article Text |
id | pubmed-10418532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Journal Experts |
record_format | MEDLINE/PubMed |
spelling | pubmed-104185322023-08-12 Antigenic diversity and dengue disease risk Wang, Lin Huang, Angkana T. Katzelnick, Leah C. Lefrancq, Noémie Escoto, Ana Coello Duret, Loréna Chowdhury, Nayeem Jarman, Richard Conte, Matthew A. Berry, Irina Maljkovic Fernandez, Stefan Klungthong, Chonticha Thaisomboonsuk, Butsaya Suntarattiwong, Piyarat Vandepitte, Warunee Whitehead, Stephen Cauchemez, Simon Cummings, Derek A.T. Salje, Henrik Res Sq Article Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection. In addition, for some pathogens such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease, through a mechanism known as antibody-dependent enhancement. However, it remains a mystery whether the antigenic distance between an individual’s first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalisations across years. Here we develop an inferential framework that combines detailed antigenic and genetic characterisation of viruses, and hospitalised cases from 21 years of surveillance in Bangkok, Thailand to identify the role of the antigenic profile of circulating viruses in determining disease risk. We find that the risk of hospitalisation depends on both the specific order of infecting serotypes and the antigenic distance between an individual’s primary and secondary infections, with risk maximised at intermediate antigenic distances. These findings suggest immune imprinting helps determine dengue disease risk, and provides a pathway to monitor the changing risk profile of populations and to quantifying risk profiles of candidate vaccines. American Journal Experts 2023-08-02 /pmc/articles/PMC10418532/ /pubmed/37577717 http://dx.doi.org/10.21203/rs.3.rs-3214507/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Wang, Lin Huang, Angkana T. Katzelnick, Leah C. Lefrancq, Noémie Escoto, Ana Coello Duret, Loréna Chowdhury, Nayeem Jarman, Richard Conte, Matthew A. Berry, Irina Maljkovic Fernandez, Stefan Klungthong, Chonticha Thaisomboonsuk, Butsaya Suntarattiwong, Piyarat Vandepitte, Warunee Whitehead, Stephen Cauchemez, Simon Cummings, Derek A.T. Salje, Henrik Antigenic diversity and dengue disease risk |
title | Antigenic diversity and dengue disease risk |
title_full | Antigenic diversity and dengue disease risk |
title_fullStr | Antigenic diversity and dengue disease risk |
title_full_unstemmed | Antigenic diversity and dengue disease risk |
title_short | Antigenic diversity and dengue disease risk |
title_sort | antigenic diversity and dengue disease risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418532/ https://www.ncbi.nlm.nih.gov/pubmed/37577717 http://dx.doi.org/10.21203/rs.3.rs-3214507/v1 |
work_keys_str_mv | AT wanglin antigenicdiversityanddenguediseaserisk AT huangangkanat antigenicdiversityanddenguediseaserisk AT katzelnickleahc antigenicdiversityanddenguediseaserisk AT lefrancqnoemie antigenicdiversityanddenguediseaserisk AT escotoanacoello antigenicdiversityanddenguediseaserisk AT duretlorena antigenicdiversityanddenguediseaserisk AT chowdhurynayeem antigenicdiversityanddenguediseaserisk AT jarmanrichard antigenicdiversityanddenguediseaserisk AT contematthewa antigenicdiversityanddenguediseaserisk AT berryirinamaljkovic antigenicdiversityanddenguediseaserisk AT fernandezstefan antigenicdiversityanddenguediseaserisk AT klungthongchonticha antigenicdiversityanddenguediseaserisk AT thaisomboonsukbutsaya antigenicdiversityanddenguediseaserisk AT suntarattiwongpiyarat antigenicdiversityanddenguediseaserisk AT vandepittewarunee antigenicdiversityanddenguediseaserisk AT whiteheadstephen antigenicdiversityanddenguediseaserisk AT cauchemezsimon antigenicdiversityanddenguediseaserisk AT cummingsderekat antigenicdiversityanddenguediseaserisk AT saljehenrik antigenicdiversityanddenguediseaserisk |