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A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL

A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biologic...

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Autores principales: Kikuchi, Shohei, Wada, Akinori, Kamihara, Yusuke, Yamamoto, Imari, Kirigaya, Daiki, Kunimoto, Kohei, Horaguchi, Ryusuke, Fujihira, Takuma, Nabe, Yoshimi, Minemura, Tomoki, Dang, Nam H., Sato, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418703/
https://www.ncbi.nlm.nih.gov/pubmed/37569526
http://dx.doi.org/10.3390/ijms241512150
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author Kikuchi, Shohei
Wada, Akinori
Kamihara, Yusuke
Yamamoto, Imari
Kirigaya, Daiki
Kunimoto, Kohei
Horaguchi, Ryusuke
Fujihira, Takuma
Nabe, Yoshimi
Minemura, Tomoki
Dang, Nam H.
Sato, Tsutomu
author_facet Kikuchi, Shohei
Wada, Akinori
Kamihara, Yusuke
Yamamoto, Imari
Kirigaya, Daiki
Kunimoto, Kohei
Horaguchi, Ryusuke
Fujihira, Takuma
Nabe, Yoshimi
Minemura, Tomoki
Dang, Nam H.
Sato, Tsutomu
author_sort Kikuchi, Shohei
collection PubMed
description A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biological factors linking the two are largely unknown. In our present study, we found no clear association between platelet count and BMD in the female group, with aging having a very strong effect on BMD. On the other hand, a significant negative correlation was found between platelet count and BMD in the male group. As a potential mechanism, we examined whether megakaryocytes, the source of platelet production, secrete cytokines that regulate BMD, namely OPG, M-CSF, and RANKL. We detected the production of these cytokines by megakaryocytes derived from bone marrow mononuclear cells, and found that RANKL was negatively correlated with BMD. This finding suggests that RANKL production by megakaryocytes may mediate the negative correlation between platelet count and BMD. To our knowledge, this is the first report to analyze bone marrow cells as a mechanism for the association between blood count and BMD. Our study may provide new insights into the development and potential treatment of osteoporosis.
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spelling pubmed-104187032023-08-12 A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL Kikuchi, Shohei Wada, Akinori Kamihara, Yusuke Yamamoto, Imari Kirigaya, Daiki Kunimoto, Kohei Horaguchi, Ryusuke Fujihira, Takuma Nabe, Yoshimi Minemura, Tomoki Dang, Nam H. Sato, Tsutomu Int J Mol Sci Article A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biological factors linking the two are largely unknown. In our present study, we found no clear association between platelet count and BMD in the female group, with aging having a very strong effect on BMD. On the other hand, a significant negative correlation was found between platelet count and BMD in the male group. As a potential mechanism, we examined whether megakaryocytes, the source of platelet production, secrete cytokines that regulate BMD, namely OPG, M-CSF, and RANKL. We detected the production of these cytokines by megakaryocytes derived from bone marrow mononuclear cells, and found that RANKL was negatively correlated with BMD. This finding suggests that RANKL production by megakaryocytes may mediate the negative correlation between platelet count and BMD. To our knowledge, this is the first report to analyze bone marrow cells as a mechanism for the association between blood count and BMD. Our study may provide new insights into the development and potential treatment of osteoporosis. MDPI 2023-07-29 /pmc/articles/PMC10418703/ /pubmed/37569526 http://dx.doi.org/10.3390/ijms241512150 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kikuchi, Shohei
Wada, Akinori
Kamihara, Yusuke
Yamamoto, Imari
Kirigaya, Daiki
Kunimoto, Kohei
Horaguchi, Ryusuke
Fujihira, Takuma
Nabe, Yoshimi
Minemura, Tomoki
Dang, Nam H.
Sato, Tsutomu
A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title_full A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title_fullStr A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title_full_unstemmed A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title_short A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
title_sort novel mechanism for bone loss: platelet count negatively correlates with bone mineral density via megakaryocyte-derived rankl
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418703/
https://www.ncbi.nlm.nih.gov/pubmed/37569526
http://dx.doi.org/10.3390/ijms241512150
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