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Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats

One of the key factors in the pathogenesis of diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on the protective properties of taxifolin spheroidal form (TS) in the streptozotocin rat model of diabetes mellitus. After 4 week...

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Autores principales: Taldaev, Amir, Savina, Anastasiya D., Olicheva, Vera V., Ivanov, Sergey V., Terekhov, Roman P., Ilyasov, Igor R., Zhevlakova, Anastasiya K., Selivanova, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418707/
https://www.ncbi.nlm.nih.gov/pubmed/37569337
http://dx.doi.org/10.3390/ijms241511962
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author Taldaev, Amir
Savina, Anastasiya D.
Olicheva, Vera V.
Ivanov, Sergey V.
Terekhov, Roman P.
Ilyasov, Igor R.
Zhevlakova, Anastasiya K.
Selivanova, Irina A.
author_facet Taldaev, Amir
Savina, Anastasiya D.
Olicheva, Vera V.
Ivanov, Sergey V.
Terekhov, Roman P.
Ilyasov, Igor R.
Zhevlakova, Anastasiya K.
Selivanova, Irina A.
author_sort Taldaev, Amir
collection PubMed
description One of the key factors in the pathogenesis of diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on the protective properties of taxifolin spheroidal form (TS) in the streptozotocin rat model of diabetes mellitus. After 4 weeks of treatment with TS, the fasting blood glucose level of the diabetic animals decreased by 12% compared with the level right after the injection of streptozotocin. While the feed intake in the untreated diabetic rats increased by 5.3% compared with the healthy group, the TS-treated group showed a pronounced 15.3% decrease. Therapeutic administration of TS has a protective effect on the pancreas and the liver against the cytotoxic action of streptozotocin. The plasma antioxidant capacity of all diabetic groups appeared to be approximately 15% lower than in healthy rats with no significant difference between the TS-treated and untreated diabetic animals. Apparently, this can be attributed to taxifolin and plasma proteins binding. These data demonstrate the potential of TS in antidiabetic therapy.
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spelling pubmed-104187072023-08-12 Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats Taldaev, Amir Savina, Anastasiya D. Olicheva, Vera V. Ivanov, Sergey V. Terekhov, Roman P. Ilyasov, Igor R. Zhevlakova, Anastasiya K. Selivanova, Irina A. Int J Mol Sci Article One of the key factors in the pathogenesis of diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on the protective properties of taxifolin spheroidal form (TS) in the streptozotocin rat model of diabetes mellitus. After 4 weeks of treatment with TS, the fasting blood glucose level of the diabetic animals decreased by 12% compared with the level right after the injection of streptozotocin. While the feed intake in the untreated diabetic rats increased by 5.3% compared with the healthy group, the TS-treated group showed a pronounced 15.3% decrease. Therapeutic administration of TS has a protective effect on the pancreas and the liver against the cytotoxic action of streptozotocin. The plasma antioxidant capacity of all diabetic groups appeared to be approximately 15% lower than in healthy rats with no significant difference between the TS-treated and untreated diabetic animals. Apparently, this can be attributed to taxifolin and plasma proteins binding. These data demonstrate the potential of TS in antidiabetic therapy. MDPI 2023-07-26 /pmc/articles/PMC10418707/ /pubmed/37569337 http://dx.doi.org/10.3390/ijms241511962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taldaev, Amir
Savina, Anastasiya D.
Olicheva, Vera V.
Ivanov, Sergey V.
Terekhov, Roman P.
Ilyasov, Igor R.
Zhevlakova, Anastasiya K.
Selivanova, Irina A.
Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title_full Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title_fullStr Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title_short Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
title_sort protective properties of spheroidal taxifolin form in streptozotocin-induced diabetic rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418707/
https://www.ncbi.nlm.nih.gov/pubmed/37569337
http://dx.doi.org/10.3390/ijms241511962
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