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Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles
Cisplatin is a first-line clinical agent used for treating solid tumors. Cisplatin damages the DNA of tumor cells and induces the production of high levels of reactive oxygen species to achieve tumor killing. Tumor cells have evolved several ways to tolerate this damage. Extracellular vesicles (EVs)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418773/ https://www.ncbi.nlm.nih.gov/pubmed/37569723 http://dx.doi.org/10.3390/ijms241512347 |
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author | Wang, Jian Liu, Qingqing Zhao, Yuanxin Fu, Jiaying Su, Jing |
author_facet | Wang, Jian Liu, Qingqing Zhao, Yuanxin Fu, Jiaying Su, Jing |
author_sort | Wang, Jian |
collection | PubMed |
description | Cisplatin is a first-line clinical agent used for treating solid tumors. Cisplatin damages the DNA of tumor cells and induces the production of high levels of reactive oxygen species to achieve tumor killing. Tumor cells have evolved several ways to tolerate this damage. Extracellular vesicles (EVs) are an important mode of information transfer in tumor cells. EVs can be substantially activated under cisplatin treatment and mediate different responses of tumor cells under cisplatin treatment depending on their different cargoes. However, the mechanism of action of tumor-cell-derived EVs under cisplatin treatment and their potential cargoes are still unclear. This review considers recent advances in cisplatin-induced release of EVs from tumor cells, with the expectation of providing a new understanding of the mechanisms of cisplatin treatment and drug resistance, as well as strategies for the combined use of cisplatin and other drugs. |
format | Online Article Text |
id | pubmed-10418773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104187732023-08-12 Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles Wang, Jian Liu, Qingqing Zhao, Yuanxin Fu, Jiaying Su, Jing Int J Mol Sci Review Cisplatin is a first-line clinical agent used for treating solid tumors. Cisplatin damages the DNA of tumor cells and induces the production of high levels of reactive oxygen species to achieve tumor killing. Tumor cells have evolved several ways to tolerate this damage. Extracellular vesicles (EVs) are an important mode of information transfer in tumor cells. EVs can be substantially activated under cisplatin treatment and mediate different responses of tumor cells under cisplatin treatment depending on their different cargoes. However, the mechanism of action of tumor-cell-derived EVs under cisplatin treatment and their potential cargoes are still unclear. This review considers recent advances in cisplatin-induced release of EVs from tumor cells, with the expectation of providing a new understanding of the mechanisms of cisplatin treatment and drug resistance, as well as strategies for the combined use of cisplatin and other drugs. MDPI 2023-08-02 /pmc/articles/PMC10418773/ /pubmed/37569723 http://dx.doi.org/10.3390/ijms241512347 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Jian Liu, Qingqing Zhao, Yuanxin Fu, Jiaying Su, Jing Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title | Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title_full | Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title_fullStr | Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title_full_unstemmed | Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title_short | Tumor Cells Transmit Drug Resistance via Cisplatin-Induced Extracellular Vesicles |
title_sort | tumor cells transmit drug resistance via cisplatin-induced extracellular vesicles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418773/ https://www.ncbi.nlm.nih.gov/pubmed/37569723 http://dx.doi.org/10.3390/ijms241512347 |
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