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Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular...

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Autores principales: Sangalli, Linda, Eli, Bradley, Mehrotra, Sachi, Sabagh, Suzan, Fricton, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418780/
https://www.ncbi.nlm.nih.gov/pubmed/37569575
http://dx.doi.org/10.3390/ijms241512200
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author Sangalli, Linda
Eli, Bradley
Mehrotra, Sachi
Sabagh, Suzan
Fricton, James
author_facet Sangalli, Linda
Eli, Bradley
Mehrotra, Sachi
Sabagh, Suzan
Fricton, James
author_sort Sangalli, Linda
collection PubMed
description A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed.
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spelling pubmed-104187802023-08-12 Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches Sangalli, Linda Eli, Bradley Mehrotra, Sachi Sabagh, Suzan Fricton, James Int J Mol Sci Review A bidirectional causal relationship has been established between temporomandibular disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic pain offer a framework for understanding the comorbidity between these two conditions that might reside in the shared biomolecular mechanisms of peripheral and central sensitization. The initiation of these processes is inflammatory in nature and is most likely mediated by key molecules, including calcitonin gene-related peptide (CGRP). This scoping review proposes that CGRP-mediated neuroinflammation in the trigeminal ganglion may partly explain the biomolecular bidirectional link between TMDs and chronic headaches. Finally, clinical implications of this neuropathologic process are briefly discussed. MDPI 2023-07-30 /pmc/articles/PMC10418780/ /pubmed/37569575 http://dx.doi.org/10.3390/ijms241512200 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sangalli, Linda
Eli, Bradley
Mehrotra, Sachi
Sabagh, Suzan
Fricton, James
Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title_full Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title_fullStr Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title_full_unstemmed Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title_short Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
title_sort calcitonin gene-related peptide-mediated trigeminal ganglionitis: the biomolecular link between temporomandibular disorders and chronic headaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418780/
https://www.ncbi.nlm.nih.gov/pubmed/37569575
http://dx.doi.org/10.3390/ijms241512200
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