Cargando…

Nutritional Provision of Iron Complexes by the Major Allergen Alt a 1 to Human Immune Cells Decreases Its Presentation

Alternaria alternata is a common fungus strongly related with severe allergic asthma, with 80% of affected individuals being sensitized solely to its major allergen Alt a 1. Here, we assessed the function of Alt a 1 as an innate defense protein binding to micronutrients, such as iron–quercetin compl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fakhimahmadi, Aila, Hasanaj, Ilir, Hofstetter, Gerlinde, Pogner, Clara, Gorfer, Markus, Wiederstein, Markus, Szepannek, Nathalie, Bianchini, Rodolfo, Dvorak, Zdenek, Jensen, Sebastian A., Berger, Markus, Jensen-Jarolim, Erika, Hufnagl, Karin, Roth-Walter, Franziska
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418924/ https://www.ncbi.nlm.nih.gov/pubmed/37569310 http://dx.doi.org/10.3390/ijms241511934

Ejemplares similares

Binding to Iron Quercetin Complexes Increases the Antioxidant Capacity of the Major Birch Pollen Allergen Bet v 1 and Reduces Its Allergenicity
por: Regner, Andreas, et al.
Publicado: (2022)

Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice
por: Hufnagl, Karin, et al.
Publicado: (2020)

Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect
por: Afify, Sheriene Moussa, et al.
Publicado: (2021)

The Major Cow Milk Allergen Bos d 5 Manipulates T-Helper Cells Depending on Its Load with Siderophore-Bound Iron
por: Roth-Walter, Franziska, et al.
Publicado: (2014)

Mimotopes for Api g 5, a Relevant Cross-reactive Allergen, in the Celery-Mugwort-Birch-Spice Syndrome
por: Lukschal, Anna, et al.
Publicado: (2016)

Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope
por: Hufnagl, Karin, et al.
Publicado: (2018)

Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH
por: Oida, Kumiko, et al.
Publicado: (2017)

Aluminium in Allergies and Allergen immunotherapy
por: Jensen-Jarolim, Erika
Publicado: (2015)

IgG4 drives M2a macrophages to a regulatory M2b‐like phenotype: potential implication in immune tolerance
por: Bianchini, Rodolfo, et al.
Publicado: (2018)

Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease
por: Hufnagl, Karin, et al.
Publicado: (2018)

Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1
por: Moreno, Antonio, et al.
Publicado: (2016)

Edible insects: Cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing
por: Pali-Schöll, Isabella, et al.
Publicado: (2019)

Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy
por: Jensen-Jarolim, Erika, et al.
Publicado: (2017)

Filling the Antibody Pipeline in Allergy: PIPE Cloning of IgE, IgG(1) and IgG(4) against the Major Birch Pollen Allergen Bet v 1
por: Köhler, Verena K., et al.
Publicado: (2020)

Dysbiosis of the gut and lung microbiome has a role in asthma
por: Hufnagl, Karin, et al.
Publicado: (2020)

Allergens in veterinary medicine
por: Mueller, R. S., et al.
Publicado: (2015)

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis
por: Jordakieva, Galateja, et al.
Publicado: (2018)

The Effect of Digestion and Digestibility on Allergenicity of Food
por: Pali-Schöll, Isabella, et al.
Publicado: (2018)

Crosstalk of carcinoembryonic antigen and transforming growth factor-β via their receptors: comparing human and canine cancer
por: Jensen-Jarolim, Erika, et al.
Publicado: (2015)

Secretory protein beta‐lactoglobulin in cattle stable dust may contribute to the allergy‐protective farm effect
por: Pali‐Schöll, Isabella, et al.
Publicado: (2022)

Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy
por: Jensen‐Jarolim, E., et al.
Publicado: (2016)

The holo beta‐lactoglobulin lozenge reduces symptoms in cat allergy—Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge
por: Bergmann, Karl‐Christian, et al.
Publicado: (2023)

Fungi Sensitization in Spain: Importance of the Alternaria alternata Species and Its Major Allergen Alt a 1 in the Allergenicity
por: López Couso, Verónica P., et al.
Publicado: (2021)

Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro
por: Gotovina, Jelena, et al.
Publicado: (2020)

Linking cross-reactivity clusters of food and respiratory allergens in PAMD@ to asthma and duration of allergy
por: Dezfouli, Shadan Ghandizadeh, et al.
Publicado: (2020)

The Role of IgG4 in the Fine Tuning of Tolerance in IgE-Mediated Allergy and Cancer
por: Bianchini, Rodolfo, et al.
Publicado: (2020)

Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses
por: Radauer-Preiml, Isabella, et al.
Publicado: (2016)

Production of the Allergenic Protein Alt a 1 by Alternaria Isolates from Working Environments
por: Skóra, Justyna, et al.
Publicado: (2015)

Functional iron‐deficiency in women with allergic rhinitis is associated with symptoms after nasal provocation and lack of iron‐sequestering microbes
por: Petje, Lisa‐Marie, et al.
Publicado: (2021)

Protein Structure Analysis and Prediction with Statistical Scoring Functions
por: Lackner, Peter, et al.
Publicado: (2021)

Changes in the Sensitization Pattern to Alternaria alternata Allergens in Patients Treated with Alt a 1 Immunotherapy
por: Rodríguez, David, et al.
Publicado: (2021)

Formulations for Allergen Immunotherapy in Human and Veterinary Patients: New Candidates on the Horizon
por: Pali-Schöll, Isabella, et al.
Publicado: (2020)

ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins
por: Wiederstein, Markus, et al.
Publicado: (2007)

Detection of Spatial Correlations in Protein Structures and Molecular Complexes
por: Sippl, Manfred J., et al.
Publicado: (2012)

TopMatch-web: pairwise matching of large assemblies of protein and nucleic acid chains in 3D
por: Wiederstein, Markus, et al.
Publicado: (2020)

Random mutagenesis and phage display technology as a tool for identifying ige epitopes of the birch pollen allergen Bet v 1
por: Guhsl, Elisabeth Eva, et al.
Publicado: (2014)

Do hypoallergenic cats exist? -- Determination of major cat allergen Fel d 1 production in normal and hypoallergenic cat breeds
por: Satorina, Julia, et al.
Publicado: (2014)

COPS—a novel workbench for explorations in fold space
por: Suhrer, Stefan J., et al.
Publicado: (2009)

Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
por: Sánchez, Patricia, et al.
Publicado: (2022)

Bet v 1 from Birch Pollen Is a Lipocalin-like Protein Acting as Allergen Only When Devoid of Iron by Promoting Th2 Lymphocytes
por: Roth-Walter, Franziska, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_digmse8aafec82m6vdca8b4708