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A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy
Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418994/ https://www.ncbi.nlm.nih.gov/pubmed/37569377 http://dx.doi.org/10.3390/ijms241512001 |
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author | Chen, Peng Zhang, Ping Shah, Navid Hussain Cui, Yanyan Wang, Yaling |
author_facet | Chen, Peng Zhang, Ping Shah, Navid Hussain Cui, Yanyan Wang, Yaling |
author_sort | Chen, Peng |
collection | PubMed |
description | Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers. |
format | Online Article Text |
id | pubmed-10418994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104189942023-08-12 A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy Chen, Peng Zhang, Ping Shah, Navid Hussain Cui, Yanyan Wang, Yaling Int J Mol Sci Review Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers. MDPI 2023-07-26 /pmc/articles/PMC10418994/ /pubmed/37569377 http://dx.doi.org/10.3390/ijms241512001 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Peng Zhang, Ping Shah, Navid Hussain Cui, Yanyan Wang, Yaling A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title_full | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title_fullStr | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title_full_unstemmed | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title_short | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
title_sort | comprehensive review of inorganic sonosensitizers for sonodynamic therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418994/ https://www.ncbi.nlm.nih.gov/pubmed/37569377 http://dx.doi.org/10.3390/ijms241512001 |
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