Cargando…

Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma

Physicochemical investigations of (UHD) solutions subjected to certain physical factors (like shaking) are becoming more frequent and increasingly yielding convincing results. A much less studied phenomenon is the transfer of molecular information (UHD signals) from one fluid to another without an i...

Descripción completa

Detalles Bibliográficos
Autores principales: Jerman, Igor, Ogrizek, Linda, Periček Krapež, Vesna, Jan, Luka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418998/
https://www.ncbi.nlm.nih.gov/pubmed/37569336
http://dx.doi.org/10.3390/ijms241511961
_version_ 1785088404377042944
author Jerman, Igor
Ogrizek, Linda
Periček Krapež, Vesna
Jan, Luka
author_facet Jerman, Igor
Ogrizek, Linda
Periček Krapež, Vesna
Jan, Luka
author_sort Jerman, Igor
collection PubMed
description Physicochemical investigations of (UHD) solutions subjected to certain physical factors (like shaking) are becoming more frequent and increasingly yielding convincing results. A much less studied phenomenon is the transfer of molecular information (UHD signals) from one fluid to another without an intermediate liquid phase. The purpose of this study was to investigate the possibility of such a UHD signal transfer from UHD solutions into the receiver fluid, especially when the molecular source used in solutions was a biologically active molecule of antibodies to interferon-gamma. We used physicochemical measurements and UV spectroscopy for this purpose. The results of this large pilot study confirm the possibility of such a transfer and a rough similarity to the original UHD signal donors, the weaker signal detection relative to the original donor fluids, and that exposure time improves the effect.
format Online
Article
Text
id pubmed-10418998
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104189982023-08-12 Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma Jerman, Igor Ogrizek, Linda Periček Krapež, Vesna Jan, Luka Int J Mol Sci Article Physicochemical investigations of (UHD) solutions subjected to certain physical factors (like shaking) are becoming more frequent and increasingly yielding convincing results. A much less studied phenomenon is the transfer of molecular information (UHD signals) from one fluid to another without an intermediate liquid phase. The purpose of this study was to investigate the possibility of such a UHD signal transfer from UHD solutions into the receiver fluid, especially when the molecular source used in solutions was a biologically active molecule of antibodies to interferon-gamma. We used physicochemical measurements and UV spectroscopy for this purpose. The results of this large pilot study confirm the possibility of such a transfer and a rough similarity to the original UHD signal donors, the weaker signal detection relative to the original donor fluids, and that exposure time improves the effect. MDPI 2023-07-26 /pmc/articles/PMC10418998/ /pubmed/37569336 http://dx.doi.org/10.3390/ijms241511961 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jerman, Igor
Ogrizek, Linda
Periček Krapež, Vesna
Jan, Luka
Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title_full Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title_fullStr Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title_full_unstemmed Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title_short Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma
title_sort physicochemical study of the molecular signal transfer of ultra-high diluted antibodies to interferon-gamma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418998/
https://www.ncbi.nlm.nih.gov/pubmed/37569336
http://dx.doi.org/10.3390/ijms241511961
work_keys_str_mv AT jermanigor physicochemicalstudyofthemolecularsignaltransferofultrahighdilutedantibodiestointerferongamma
AT ogrizeklinda physicochemicalstudyofthemolecularsignaltransferofultrahighdilutedantibodiestointerferongamma
AT pericekkrapezvesna physicochemicalstudyofthemolecularsignaltransferofultrahighdilutedantibodiestointerferongamma
AT janluka physicochemicalstudyofthemolecularsignaltransferofultrahighdilutedantibodiestointerferongamma