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Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement
Inflammatory bowel diseases (IBDs) represent chronic idiopathic disorders, including Crohn’s disease (CD) and ulcerative colitis (UC), in which one of the trigger factors is represented by aberrant immune interactions between the intestinal epithelium and the intestinal microbiota. The involvement o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419025/ https://www.ncbi.nlm.nih.gov/pubmed/37569505 http://dx.doi.org/10.3390/ijms241512129 |
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author | Federica, Scalia Francesco, Carini Sabrina, David Marco, Giammanco Margherita, Mazzola Francesca, Rappa Noemi Irma, Bressan Giorgio, Maida Giovanni, Tomasello |
author_facet | Federica, Scalia Francesco, Carini Sabrina, David Marco, Giammanco Margherita, Mazzola Francesca, Rappa Noemi Irma, Bressan Giorgio, Maida Giovanni, Tomasello |
author_sort | Federica, Scalia |
collection | PubMed |
description | Inflammatory bowel diseases (IBDs) represent chronic idiopathic disorders, including Crohn’s disease (CD) and ulcerative colitis (UC), in which one of the trigger factors is represented by aberrant immune interactions between the intestinal epithelium and the intestinal microbiota. The involvement of heat shock proteins (HSPs) as etiological and pathogenetic factors is becoming of increasing interest. HSPs were found to be differentially expressed in the intestinal tissues and sera of patients with CD and UC. It has been shown that HSPs can play a dual role in the disease, depending on the stage of progression. They can support the inflammatory and fibrosis process, but they can also act as protective factors during disease progression or before the onset of one of the worst complications of IBD, colorectal cancer. Furthermore, HSPs are able to mediate the interaction between the intestinal microbiota and intestinal epithelial cells. In this work, we discuss the involvement of HSPs in IBD considering their genetic, epigenetic, immune and molecular roles, referring to the most recent works present in the literature. With our review, we want to shed light on the importance of further exploring the role of HSPs, or even better, the role of the molecular chaperone system (CS), in IBD: various molecules of the CS including HSPs may have diagnostic, prognostic and therapeutic potential, promoting the creation of new drugs that could overcome the side-effects of the therapies currently used. |
format | Online Article Text |
id | pubmed-10419025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104190252023-08-12 Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement Federica, Scalia Francesco, Carini Sabrina, David Marco, Giammanco Margherita, Mazzola Francesca, Rappa Noemi Irma, Bressan Giorgio, Maida Giovanni, Tomasello Int J Mol Sci Review Inflammatory bowel diseases (IBDs) represent chronic idiopathic disorders, including Crohn’s disease (CD) and ulcerative colitis (UC), in which one of the trigger factors is represented by aberrant immune interactions between the intestinal epithelium and the intestinal microbiota. The involvement of heat shock proteins (HSPs) as etiological and pathogenetic factors is becoming of increasing interest. HSPs were found to be differentially expressed in the intestinal tissues and sera of patients with CD and UC. It has been shown that HSPs can play a dual role in the disease, depending on the stage of progression. They can support the inflammatory and fibrosis process, but they can also act as protective factors during disease progression or before the onset of one of the worst complications of IBD, colorectal cancer. Furthermore, HSPs are able to mediate the interaction between the intestinal microbiota and intestinal epithelial cells. In this work, we discuss the involvement of HSPs in IBD considering their genetic, epigenetic, immune and molecular roles, referring to the most recent works present in the literature. With our review, we want to shed light on the importance of further exploring the role of HSPs, or even better, the role of the molecular chaperone system (CS), in IBD: various molecules of the CS including HSPs may have diagnostic, prognostic and therapeutic potential, promoting the creation of new drugs that could overcome the side-effects of the therapies currently used. MDPI 2023-07-28 /pmc/articles/PMC10419025/ /pubmed/37569505 http://dx.doi.org/10.3390/ijms241512129 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Federica, Scalia Francesco, Carini Sabrina, David Marco, Giammanco Margherita, Mazzola Francesca, Rappa Noemi Irma, Bressan Giorgio, Maida Giovanni, Tomasello Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title | Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title_full | Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title_fullStr | Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title_full_unstemmed | Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title_short | Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement |
title_sort | inflammatory bowel diseases: an updated overview on the heat shock protein involvement |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419025/ https://www.ncbi.nlm.nih.gov/pubmed/37569505 http://dx.doi.org/10.3390/ijms241512129 |
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