Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells

NADPH:thioredoxin reductase (TrxR) is considered a potential target for anticancer agents. Several nitroheterocyclic sulfones, such as Stattic and Tri-1, irreversibly inhibit TrxR, which presumably accounts for their antitumor activity. However, it is necessary to distinguish the roles of enzymatic...

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Detalles Bibliográficos
Autores principales: Nemeikaitė-Čėnienė, Aušra, Misevičienė, Lina, Marozienė, Audronė, Jonušienė, Violeta, Čėnas, Narimantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419047/
https://www.ncbi.nlm.nih.gov/pubmed/37569833
http://dx.doi.org/10.3390/ijms241512460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419047/
https://www.ncbi.nlm.nih.gov/pubmed/37569833
http://dx.doi.org/10.3390/ijms241512460

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