Cargando…

Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells

NADPH:thioredoxin reductase (TrxR) is considered a potential target for anticancer agents. Several nitroheterocyclic sulfones, such as Stattic and Tri-1, irreversibly inhibit TrxR, which presumably accounts for their antitumor activity. However, it is necessary to distinguish the roles of enzymatic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nemeikaitė-Čėnienė, Aušra, Misevičienė, Lina, Marozienė, Audronė, Jonušienė, Violeta, Čėnas, Narimantas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419047/ https://www.ncbi.nlm.nih.gov/pubmed/37569833 http://dx.doi.org/10.3390/ijms241512460

Ejemplares similares

Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2020)

Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2019)

Single- and Two-Electron Reduction of Nitroaromatic Compounds by Flavoenzymes: Mechanisms and Implications for Cytotoxicity
por: Čėnas, Narimantas, et al.
Publicado: (2021)

Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2023)

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase
por: Marozienė, Audronė, et al.
Publicado: (2019)

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step
por: Valiauga, Benjaminas, et al.
Publicado: (2018)

Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives
por: Peciukaityte-Alksne, Milda, et al.
Publicado: (2017)

The Study of NADPH-Dependent Flavoenzyme-Catalyzed Reduction of Benzo[1,2-c]1,2,5-oxadiazole N-Oxides (Benzofuroxans)
por: Šarlauskas, Jonas, et al.
Publicado: (2014)

Thioredoxin Reductase-Type Ferredoxin: NADP(+) Oxidoreductase of Rhodopseudomonas palustris: Potentiometric Characteristics and Reactions with Nonphysiological Oxidants
por: Lesanavičius, Mindaugas, et al.
Publicado: (2022)

Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells
por: Anestål, Karin, et al.
Publicado: (2008)

Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase
por: Jenny, Kaelyn A., et al.
Publicado: (2022)

Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells
por: Wright, David E., et al.
Publicado: (2022)

Reactions of Recombinant Neuronal Nitric Oxide Synthase with Redox Cycling Xenobiotics: A Mechanistic Study
por: Lesanavičius, Mindaugas, et al.
Publicado: (2022)

Reactions of Plasmodium falciparum Ferredoxin:NADP(+) Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study
por: Lesanavičius, Mindaugas, et al.
Publicado: (2020)

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
por: Selenius, Markus, et al.
Publicado: (2012)

MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1
por: Kline, Chelsey D., et al.
Publicado: (2022)

Disequilibrium in the Thioredoxin Reductase-1/Thioredoxin-1 Redox Couple Is Associated with Increased T-Cell Apoptosis in Children with Autism
por: Alshehri, Samiyah, et al.
Publicado: (2023)

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function
por: Stancill, Jennifer S, et al.
Publicado: (2022)

Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?
por: Lothrop, Adam P., et al.
Publicado: (2014)

Chlorophyllin Inhibits Mammalian Thioredoxin Reductase 1 and Triggers Cancer Cell Death
por: Sun, Shibo, et al.
Publicado: (2021)

Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant, Methylmercury
por: Alshehri, Samiyah, et al.
Publicado: (2023)

Redox Regulation of Monodehydroascorbate Reductase by Thioredoxin y in Plastids Revealed in the Context of Water Stress
por: Vanacker, Hélène, et al.
Publicado: (2018)

Thioredoxin Reductase and its Inhibitors
por: Saccoccia, Fulvio, et al.
Publicado: (2014)

Study of the cytotoxic effects of 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone (MeDZQ) in mouse hepatoma cells
por: Jarasiene-Burinskaja, Rasa, et al.
Publicado: (2017)

Structural Insights into Interaction between Mammalian Methionine Sulfoxide Reductase B1 and Thioredoxin
por: Dobrovolska, Olena, et al.
Publicado: (2012)

Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives
por: Song, Zilong, et al.
Publicado: (2023)

A Mechanistic Investigation of the C-Terminal Redox Motif of Thioredoxin Reductase from Plasmodium falciparum
por: Snider, Gregg W., et al.
Publicado: (2014)

The Role of Thioredoxin Reductases in Brain Development
por: Soerensen, Jonna, et al.
Publicado: (2008)

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
por: Prigge, Justin R., et al.
Publicado: (2017)

Direct Electrochemical Analyses of a Thermophilic Thioredoxin Reductase: Interplay between Conformational Change and Redox Chemistry
por: Hamill, Michael J., et al.
Publicado: (2008)

Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
por: Chethna, Pogakula, et al.
Publicado: (2018)

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
por: Cadenas, Cristina, et al.
Publicado: (2010)

Expression of Thioredoxin/Thioredoxin Reductase System Genes in Aphid-Challenged Maize Seedlings
por: Sytykiewicz, Hubert, et al.
Publicado: (2020)

Editorial: Small molecule inhibitors targeting mammalian selenoprotein thioredoxin reductases (TXNRDs): Interactions, mechanisms, and applications
por: Xu, Jianqiang, et al.
Publicado: (2023)

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense
por: Lin, Kan, et al.
Publicado: (2016)

The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity
por: Prasad, Chandra Bhushan, et al.
Publicado: (2023)

Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity
por: Wright, David E., et al.
Publicado: (2018)

Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in vivo function of reductase and thioredoxin domains
por: Toivola, Jouni, et al.
Publicado: (2013)

Characterizing Roles for the Glutathione Reductase, Thioredoxin Reductase and Thioredoxin Peroxidase-Encoding Genes of Magnaporthe oryzae during Rice Blast Disease
por: Fernandez, Jessie, et al.
Publicado: (2014)

Structural Factors That Determine the Activity of the Xenobiotic Reductase B Enzyme from Pseudomonas putida on Nitroaromatic Compounds
por: Osorio, Manuel I., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_62q1r3f9h96t0ob3gmpvbhvre1