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Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage

Central nervous system (CNS) infections including meningitis and encephalitis, resulting from the blood-borne spread of specific microorganisms, provoke nervous tissue damage due to the inflammatory process. Moreover, different pathologies such as sepsis can generate systemic inflammation. Bacterial...

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Autores principales: Millán Solano, Mara Verónica, Salinas Lara, Citlaltepetl, Sánchez-Garibay, Carlos, Soto-Rojas, Luis O., Escobedo-Ávila, Itzel, Tena-Suck, Martha Lilia, Ortíz-Butrón, Rocío, Choreño-Parra, José Alberto, Romero-López, José Pablo, Meléndez Camargo, María Estela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419139/
https://www.ncbi.nlm.nih.gov/pubmed/37569277
http://dx.doi.org/10.3390/ijms241511902
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author Millán Solano, Mara Verónica
Salinas Lara, Citlaltepetl
Sánchez-Garibay, Carlos
Soto-Rojas, Luis O.
Escobedo-Ávila, Itzel
Tena-Suck, Martha Lilia
Ortíz-Butrón, Rocío
Choreño-Parra, José Alberto
Romero-López, José Pablo
Meléndez Camargo, María Estela
author_facet Millán Solano, Mara Verónica
Salinas Lara, Citlaltepetl
Sánchez-Garibay, Carlos
Soto-Rojas, Luis O.
Escobedo-Ávila, Itzel
Tena-Suck, Martha Lilia
Ortíz-Butrón, Rocío
Choreño-Parra, José Alberto
Romero-López, José Pablo
Meléndez Camargo, María Estela
author_sort Millán Solano, Mara Verónica
collection PubMed
description Central nervous system (CNS) infections including meningitis and encephalitis, resulting from the blood-borne spread of specific microorganisms, provoke nervous tissue damage due to the inflammatory process. Moreover, different pathologies such as sepsis can generate systemic inflammation. Bacterial lipopolysaccharide (LPS) induces the release of inflammatory mediators and damage molecules, which are then released into the bloodstream and can interact with structures such as the CNS, thus modifying the blood–brain barrier’s (BBB´s) and blood–cerebrospinal fluid barrier´s (BCSFB´s) function and inducing aseptic neuroinflammation. During neuroinflammation, the participation of glial cells (astrocytes, microglia, and oligodendrocytes) plays an important role. They release cytokines, chemokines, reactive oxygen species, nitrogen species, peptides, and even excitatory amino acids that lead to neuronal damage. The neurons undergo morphological and functional changes that could initiate functional alterations to neurodegenerative processes. The present work aims to explain these processes and the pathophysiological interactions involved in CNS damage in the absence of microbes or inflammatory cells.
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spelling pubmed-104191392023-08-12 Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage Millán Solano, Mara Verónica Salinas Lara, Citlaltepetl Sánchez-Garibay, Carlos Soto-Rojas, Luis O. Escobedo-Ávila, Itzel Tena-Suck, Martha Lilia Ortíz-Butrón, Rocío Choreño-Parra, José Alberto Romero-López, José Pablo Meléndez Camargo, María Estela Int J Mol Sci Review Central nervous system (CNS) infections including meningitis and encephalitis, resulting from the blood-borne spread of specific microorganisms, provoke nervous tissue damage due to the inflammatory process. Moreover, different pathologies such as sepsis can generate systemic inflammation. Bacterial lipopolysaccharide (LPS) induces the release of inflammatory mediators and damage molecules, which are then released into the bloodstream and can interact with structures such as the CNS, thus modifying the blood–brain barrier’s (BBB´s) and blood–cerebrospinal fluid barrier´s (BCSFB´s) function and inducing aseptic neuroinflammation. During neuroinflammation, the participation of glial cells (astrocytes, microglia, and oligodendrocytes) plays an important role. They release cytokines, chemokines, reactive oxygen species, nitrogen species, peptides, and even excitatory amino acids that lead to neuronal damage. The neurons undergo morphological and functional changes that could initiate functional alterations to neurodegenerative processes. The present work aims to explain these processes and the pathophysiological interactions involved in CNS damage in the absence of microbes or inflammatory cells. MDPI 2023-07-25 /pmc/articles/PMC10419139/ /pubmed/37569277 http://dx.doi.org/10.3390/ijms241511902 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Millán Solano, Mara Verónica
Salinas Lara, Citlaltepetl
Sánchez-Garibay, Carlos
Soto-Rojas, Luis O.
Escobedo-Ávila, Itzel
Tena-Suck, Martha Lilia
Ortíz-Butrón, Rocío
Choreño-Parra, José Alberto
Romero-López, José Pablo
Meléndez Camargo, María Estela
Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title_full Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title_fullStr Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title_full_unstemmed Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title_short Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
title_sort effect of systemic inflammation in the cns: a silent history of neuronal damage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419139/
https://www.ncbi.nlm.nih.gov/pubmed/37569277
http://dx.doi.org/10.3390/ijms241511902
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