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YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategie...

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Detalles Bibliográficos
Autores principales: Huang, Miao, Wang, Heyang, Mackey, Cole, Chung, Michael C., Guan, Juan, Zheng, Guangrong, Roy, Arkaprava, Xie, Mingyi, Vulpe, Christopher, Tang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419175/
https://www.ncbi.nlm.nih.gov/pubmed/37569866
http://dx.doi.org/10.3390/ijms241512491
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author Huang, Miao
Wang, Heyang
Mackey, Cole
Chung, Michael C.
Guan, Juan
Zheng, Guangrong
Roy, Arkaprava
Xie, Mingyi
Vulpe, Christopher
Tang, Xin
author_facet Huang, Miao
Wang, Heyang
Mackey, Cole
Chung, Michael C.
Guan, Juan
Zheng, Guangrong
Roy, Arkaprava
Xie, Mingyi
Vulpe, Christopher
Tang, Xin
author_sort Huang, Miao
collection PubMed
description Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis.
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spelling pubmed-104191752023-08-12 YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer Huang, Miao Wang, Heyang Mackey, Cole Chung, Michael C. Guan, Juan Zheng, Guangrong Roy, Arkaprava Xie, Mingyi Vulpe, Christopher Tang, Xin Int J Mol Sci Review Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis. MDPI 2023-08-06 /pmc/articles/PMC10419175/ /pubmed/37569866 http://dx.doi.org/10.3390/ijms241512491 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Miao
Wang, Heyang
Mackey, Cole
Chung, Michael C.
Guan, Juan
Zheng, Guangrong
Roy, Arkaprava
Xie, Mingyi
Vulpe, Christopher
Tang, Xin
YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title_full YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title_fullStr YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title_full_unstemmed YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title_short YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
title_sort yap at the crossroads of biomechanics and drug resistance in human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419175/
https://www.ncbi.nlm.nih.gov/pubmed/37569866
http://dx.doi.org/10.3390/ijms241512491
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