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YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer
Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419175/ https://www.ncbi.nlm.nih.gov/pubmed/37569866 http://dx.doi.org/10.3390/ijms241512491 |
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author | Huang, Miao Wang, Heyang Mackey, Cole Chung, Michael C. Guan, Juan Zheng, Guangrong Roy, Arkaprava Xie, Mingyi Vulpe, Christopher Tang, Xin |
author_facet | Huang, Miao Wang, Heyang Mackey, Cole Chung, Michael C. Guan, Juan Zheng, Guangrong Roy, Arkaprava Xie, Mingyi Vulpe, Christopher Tang, Xin |
author_sort | Huang, Miao |
collection | PubMed |
description | Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis. |
format | Online Article Text |
id | pubmed-10419175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104191752023-08-12 YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer Huang, Miao Wang, Heyang Mackey, Cole Chung, Michael C. Guan, Juan Zheng, Guangrong Roy, Arkaprava Xie, Mingyi Vulpe, Christopher Tang, Xin Int J Mol Sci Review Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis. MDPI 2023-08-06 /pmc/articles/PMC10419175/ /pubmed/37569866 http://dx.doi.org/10.3390/ijms241512491 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Huang, Miao Wang, Heyang Mackey, Cole Chung, Michael C. Guan, Juan Zheng, Guangrong Roy, Arkaprava Xie, Mingyi Vulpe, Christopher Tang, Xin YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title | YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title_full | YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title_fullStr | YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title_full_unstemmed | YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title_short | YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer |
title_sort | yap at the crossroads of biomechanics and drug resistance in human cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419175/ https://www.ncbi.nlm.nih.gov/pubmed/37569866 http://dx.doi.org/10.3390/ijms241512491 |
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