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Nanotechnology boosts the efficiency of tumor diagnosis and therapy
The incidence and mortality of cancer are gradually increasing. The highly invasive and metastasis of tumor cells increase the difficulty of diagnosis and treatment, so people pay more and more attention to the diagnosis and treatment of cancer. Conventional treatment methods, including surgery, rad...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419217/ https://www.ncbi.nlm.nih.gov/pubmed/37576984 http://dx.doi.org/10.3389/fbioe.2023.1249875 |
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author | Yang, Ying Lin, Mali Sun, Mengfan Zhang, Guo-Qiang Guo, Jianshuang Li, Jianheng |
author_facet | Yang, Ying Lin, Mali Sun, Mengfan Zhang, Guo-Qiang Guo, Jianshuang Li, Jianheng |
author_sort | Yang, Ying |
collection | PubMed |
description | The incidence and mortality of cancer are gradually increasing. The highly invasive and metastasis of tumor cells increase the difficulty of diagnosis and treatment, so people pay more and more attention to the diagnosis and treatment of cancer. Conventional treatment methods, including surgery, radiotherapy and chemotherapy, are difficult to eliminate tumor cells completely. And the emergence of nanotechnology has boosted the efficiency of tumor diagnosis and therapy. Herein, the research progress of nanotechnology used for tumor diagnosis and treatment is reviewed, and the emerging detection technology and the application of nanodrugs in clinic are summarized and prospected. The first part refers to the application of different nanomaterials for imaging in vivo and detection in vitro, which includes magnetic resonance imaging, fluorescence imaging, photoacoustic imaging and biomarker detection. The distinctive physical and chemical advantages of nanomaterials can improve the detection sensitivity and accuracy to achieve tumor detection in early stage. The second part is about the nanodrug used in clinic for tumor treatment. Nanomaterials have been widely used as drug carriers, including the albumin paclitaxel, liposome drugs, mRNA-LNP, protein nanocages, micelles, membrane nanocomplexes, microspheres et al., which could improve the drug accumulate in tumor tissue through enhanced permeability and retention effect to kill tumor cells with high efficiency. But there are still some challenges to revolutionize traditional tumor diagnosis and anti-drug resistance based on nanotechnology. |
format | Online Article Text |
id | pubmed-10419217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104192172023-08-12 Nanotechnology boosts the efficiency of tumor diagnosis and therapy Yang, Ying Lin, Mali Sun, Mengfan Zhang, Guo-Qiang Guo, Jianshuang Li, Jianheng Front Bioeng Biotechnol Bioengineering and Biotechnology The incidence and mortality of cancer are gradually increasing. The highly invasive and metastasis of tumor cells increase the difficulty of diagnosis and treatment, so people pay more and more attention to the diagnosis and treatment of cancer. Conventional treatment methods, including surgery, radiotherapy and chemotherapy, are difficult to eliminate tumor cells completely. And the emergence of nanotechnology has boosted the efficiency of tumor diagnosis and therapy. Herein, the research progress of nanotechnology used for tumor diagnosis and treatment is reviewed, and the emerging detection technology and the application of nanodrugs in clinic are summarized and prospected. The first part refers to the application of different nanomaterials for imaging in vivo and detection in vitro, which includes magnetic resonance imaging, fluorescence imaging, photoacoustic imaging and biomarker detection. The distinctive physical and chemical advantages of nanomaterials can improve the detection sensitivity and accuracy to achieve tumor detection in early stage. The second part is about the nanodrug used in clinic for tumor treatment. Nanomaterials have been widely used as drug carriers, including the albumin paclitaxel, liposome drugs, mRNA-LNP, protein nanocages, micelles, membrane nanocomplexes, microspheres et al., which could improve the drug accumulate in tumor tissue through enhanced permeability and retention effect to kill tumor cells with high efficiency. But there are still some challenges to revolutionize traditional tumor diagnosis and anti-drug resistance based on nanotechnology. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10419217/ /pubmed/37576984 http://dx.doi.org/10.3389/fbioe.2023.1249875 Text en Copyright © 2023 Yang, Lin, Sun, Zhang, Guo and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Yang, Ying Lin, Mali Sun, Mengfan Zhang, Guo-Qiang Guo, Jianshuang Li, Jianheng Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title | Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title_full | Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title_fullStr | Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title_full_unstemmed | Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title_short | Nanotechnology boosts the efficiency of tumor diagnosis and therapy |
title_sort | nanotechnology boosts the efficiency of tumor diagnosis and therapy |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419217/ https://www.ncbi.nlm.nih.gov/pubmed/37576984 http://dx.doi.org/10.3389/fbioe.2023.1249875 |
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