Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications

The human P-glycoprotein (P-gp), a transporter responsible for multidrug resistance, is present in the plasma membrane’s raft and non-raft domains. One specific conformation of P-gp that binds to the monoclonal antibody UIC2 is primarily associated with raft domains and displays heightened internali...

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Detalles Bibliográficos
Autores principales: Gutay-Tóth, Zsuzsanna, Gellen, Gabriella, Doan, Minh, Eliason, James F., Vincze, János, Szente, Lajos, Fenyvesi, Ferenc, Goda, Katalin, Vecsernyés, Miklós, Szabó, Gábor, Bacso, Zsolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419235/
https://www.ncbi.nlm.nih.gov/pubmed/37569709
http://dx.doi.org/10.3390/ijms241512335

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