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Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology

NURR1 (Nuclear receptor-related 1 protein or NR4A2) is a nuclear protein receptor transcription factor with an essential role in the development, regulation, and maintenance of dopaminergic neurons and mediates the response to stressful stimuli during the perinatal period in mammalian brain developm...

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Autores principales: García-Yagüe, Ángel Juan, Cuadrado, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419244/
https://www.ncbi.nlm.nih.gov/pubmed/37569656
http://dx.doi.org/10.3390/ijms241512280
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author García-Yagüe, Ángel Juan
Cuadrado, Antonio
author_facet García-Yagüe, Ángel Juan
Cuadrado, Antonio
author_sort García-Yagüe, Ángel Juan
collection PubMed
description NURR1 (Nuclear receptor-related 1 protein or NR4A2) is a nuclear protein receptor transcription factor with an essential role in the development, regulation, and maintenance of dopaminergic neurons and mediates the response to stressful stimuli during the perinatal period in mammalian brain development. The dysregulation of NURR1 activity may play a role in various diseases, including the onset and progression of neurodegenerative diseases, and several other pathologies. NURR1 is regulated by multiple mechanisms, among which phosphorylation by kinases or SUMOylation are the best characterized. Both post-translational modifications can regulate the activity of NURR1, affecting its stability and transcriptional activity. Other non-post-translational regulatory mechanisms include changes in its subcellular distribution or interaction with other protein partners by heterodimerization, also affecting its transcription activity. Here, we summarize the currently known regulatory mechanisms of NURR1 and provide a brief overview of its participation in pathological alterations.
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spelling pubmed-104192442023-08-12 Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology García-Yagüe, Ángel Juan Cuadrado, Antonio Int J Mol Sci Review NURR1 (Nuclear receptor-related 1 protein or NR4A2) is a nuclear protein receptor transcription factor with an essential role in the development, regulation, and maintenance of dopaminergic neurons and mediates the response to stressful stimuli during the perinatal period in mammalian brain development. The dysregulation of NURR1 activity may play a role in various diseases, including the onset and progression of neurodegenerative diseases, and several other pathologies. NURR1 is regulated by multiple mechanisms, among which phosphorylation by kinases or SUMOylation are the best characterized. Both post-translational modifications can regulate the activity of NURR1, affecting its stability and transcriptional activity. Other non-post-translational regulatory mechanisms include changes in its subcellular distribution or interaction with other protein partners by heterodimerization, also affecting its transcription activity. Here, we summarize the currently known regulatory mechanisms of NURR1 and provide a brief overview of its participation in pathological alterations. MDPI 2023-07-31 /pmc/articles/PMC10419244/ /pubmed/37569656 http://dx.doi.org/10.3390/ijms241512280 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Yagüe, Ángel Juan
Cuadrado, Antonio
Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title_full Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title_fullStr Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title_full_unstemmed Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title_short Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
title_sort mechanisms of nurr1 regulation: consequences for its biological activity and involvement in pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419244/
https://www.ncbi.nlm.nih.gov/pubmed/37569656
http://dx.doi.org/10.3390/ijms241512280
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