The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures

PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signa...

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Autores principales: Wu, Yu-Nuo, Su, Xing, Wang, Xue-Qin, Liu, Na-Na, Xu, Zhou-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419273/
https://www.ncbi.nlm.nih.gov/pubmed/37576896
http://dx.doi.org/10.3389/fonc.2023.1231875
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author Wu, Yu-Nuo
Su, Xing
Wang, Xue-Qin
Liu, Na-Na
Xu, Zhou-Wei
author_facet Wu, Yu-Nuo
Su, Xing
Wang, Xue-Qin
Liu, Na-Na
Xu, Zhou-Wei
author_sort Wu, Yu-Nuo
collection PubMed
description PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signals can promote or inhibit the occurrence and development of cancer by affecting the growth, differentiation and metastasis of cells, while targeted intervention of PLC-β1-PI3K-AKT, PLC-β2/CD133, CXCR2-NHERF1-PLC-β3, Gαq-PLC-β4-PKC-MAPK and so on can provide new strategies for the precise prevention and treatment of malignant tumors. This paper reviews the mechanism of PLC-β in various tumor cells from four aspects: proliferation and differentiation, invasion and metastasis, angiogenesis and protective measures.
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spelling pubmed-104192732023-08-12 The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures Wu, Yu-Nuo Su, Xing Wang, Xue-Qin Liu, Na-Na Xu, Zhou-Wei Front Oncol Oncology PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signals can promote or inhibit the occurrence and development of cancer by affecting the growth, differentiation and metastasis of cells, while targeted intervention of PLC-β1-PI3K-AKT, PLC-β2/CD133, CXCR2-NHERF1-PLC-β3, Gαq-PLC-β4-PKC-MAPK and so on can provide new strategies for the precise prevention and treatment of malignant tumors. This paper reviews the mechanism of PLC-β in various tumor cells from four aspects: proliferation and differentiation, invasion and metastasis, angiogenesis and protective measures. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10419273/ /pubmed/37576896 http://dx.doi.org/10.3389/fonc.2023.1231875 Text en Copyright © 2023 Wu, Su, Wang, Liu and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Yu-Nuo
Su, Xing
Wang, Xue-Qin
Liu, Na-Na
Xu, Zhou-Wei
The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title_full The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title_fullStr The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title_full_unstemmed The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title_short The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
title_sort roles of phospholipase c-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419273/
https://www.ncbi.nlm.nih.gov/pubmed/37576896
http://dx.doi.org/10.3389/fonc.2023.1231875
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