Cargando…

Association between creatine phosphokinase level within normal range and bone mineral density in adolescents

Currently, it is unclear whether creatine phosphokinase (CPK) affects bone mineral density (BMD) in adolescents. We sought to clarify the relationship between CPK and total BMD in adolescents aged 12 to 19 years within normal values by conducting this study. A cross-sectional study was conducted usi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhenwei, Du, Weibin, Han, Meichun, He, Lihong, Zhang, Hongwei, Hu, Jintao, Quan, Renfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419352/
https://www.ncbi.nlm.nih.gov/pubmed/37565924
http://dx.doi.org/10.1097/MD.0000000000034724
_version_ 1785088496767074304
author Wang, Zhenwei
Du, Weibin
Han, Meichun
He, Lihong
Zhang, Hongwei
Hu, Jintao
Quan, Renfu
author_facet Wang, Zhenwei
Du, Weibin
Han, Meichun
He, Lihong
Zhang, Hongwei
Hu, Jintao
Quan, Renfu
author_sort Wang, Zhenwei
collection PubMed
description Currently, it is unclear whether creatine phosphokinase (CPK) affects bone mineral density (BMD) in adolescents. We sought to clarify the relationship between CPK and total BMD in adolescents aged 12 to 19 years within normal values by conducting this study. A cross-sectional study was conducted using the 2011 to 2018 National Health and Nutrition Survey data to examine 1188 males (average age, 15.2 years) and 1629 females (average age, 15.4 years). In this study, CPK was the independent variable and total BMD was the outcome variable. In addition to using multivariate linear regression models, subgroup analyses were also conducted in order to examine the relationship between CPK levels and total BMD within normal ranges. Significant positive association was observed between the CPK levels and total BMD in adolescents (model 1: 0.0003 [0.0002, 0.0004], model 2: 0.0004 [0.0003, 0.0005] and model 3: 0.0004 [0.0003, 0.0004]). After adjusting for age, gender, race/ethnicity, body mass index, dietary protein intake, dietary protein intake, dietary fiber intake, poverty to income ratio, physical activities, total cholesterol, total protein, blood urea nitrogen, phosphorus, and serum calcium, CPK levels remained significantly associated with BMD (regression coefficients for quartiles 2 to 4 vs quartile1 were 0.0002, 0.0072, and 0.0154, respectively; P for trend <.001). The association was positive even when stratified by age, gender, and race. Further, adolescents aged 16 to 19 years were more likely to report positive relationships than adolescents aged 12 to 15 years. And the phase relationship between total BMD and CPK was further enhanced in boys. The results of our study show that CPK levels within the normal range are positively associated with total BMD in adolescents aged 12 to 19 years. Additionally, CPK may be a potential biomarker of bone health among adolescents.
format Online
Article
Text
id pubmed-10419352
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-104193522023-08-12 Association between creatine phosphokinase level within normal range and bone mineral density in adolescents Wang, Zhenwei Du, Weibin Han, Meichun He, Lihong Zhang, Hongwei Hu, Jintao Quan, Renfu Medicine (Baltimore) 6600 Currently, it is unclear whether creatine phosphokinase (CPK) affects bone mineral density (BMD) in adolescents. We sought to clarify the relationship between CPK and total BMD in adolescents aged 12 to 19 years within normal values by conducting this study. A cross-sectional study was conducted using the 2011 to 2018 National Health and Nutrition Survey data to examine 1188 males (average age, 15.2 years) and 1629 females (average age, 15.4 years). In this study, CPK was the independent variable and total BMD was the outcome variable. In addition to using multivariate linear regression models, subgroup analyses were also conducted in order to examine the relationship between CPK levels and total BMD within normal ranges. Significant positive association was observed between the CPK levels and total BMD in adolescents (model 1: 0.0003 [0.0002, 0.0004], model 2: 0.0004 [0.0003, 0.0005] and model 3: 0.0004 [0.0003, 0.0004]). After adjusting for age, gender, race/ethnicity, body mass index, dietary protein intake, dietary protein intake, dietary fiber intake, poverty to income ratio, physical activities, total cholesterol, total protein, blood urea nitrogen, phosphorus, and serum calcium, CPK levels remained significantly associated with BMD (regression coefficients for quartiles 2 to 4 vs quartile1 were 0.0002, 0.0072, and 0.0154, respectively; P for trend <.001). The association was positive even when stratified by age, gender, and race. Further, adolescents aged 16 to 19 years were more likely to report positive relationships than adolescents aged 12 to 15 years. And the phase relationship between total BMD and CPK was further enhanced in boys. The results of our study show that CPK levels within the normal range are positively associated with total BMD in adolescents aged 12 to 19 years. Additionally, CPK may be a potential biomarker of bone health among adolescents. Lippincott Williams & Wilkins 2023-08-11 /pmc/articles/PMC10419352/ /pubmed/37565924 http://dx.doi.org/10.1097/MD.0000000000034724 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 6600
Wang, Zhenwei
Du, Weibin
Han, Meichun
He, Lihong
Zhang, Hongwei
Hu, Jintao
Quan, Renfu
Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title_full Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title_fullStr Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title_full_unstemmed Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title_short Association between creatine phosphokinase level within normal range and bone mineral density in adolescents
title_sort association between creatine phosphokinase level within normal range and bone mineral density in adolescents
topic 6600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419352/
https://www.ncbi.nlm.nih.gov/pubmed/37565924
http://dx.doi.org/10.1097/MD.0000000000034724
work_keys_str_mv AT wangzhenwei associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT duweibin associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT hanmeichun associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT helihong associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT zhanghongwei associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT hujintao associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents
AT quanrenfu associationbetweencreatinephosphokinaselevelwithinnormalrangeandbonemineraldensityinadolescents