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Hypertensive Heart Failure
Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to heart failure (HF) development has been undermined in current clinical practice. This is because approximately half of HF patients have been labeled as suffering from HF with preserved left ventricular (LV) ejec...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419453/ https://www.ncbi.nlm.nih.gov/pubmed/37568493 http://dx.doi.org/10.3390/jcm12155090 |
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author | Triposkiadis, Filippos Sarafidis, Pantelis Briasoulis, Alexandros Magouliotis, Dimitrios E. Athanasiou, Thanos Skoularigis, John Xanthopoulos, Andrew |
author_facet | Triposkiadis, Filippos Sarafidis, Pantelis Briasoulis, Alexandros Magouliotis, Dimitrios E. Athanasiou, Thanos Skoularigis, John Xanthopoulos, Andrew |
author_sort | Triposkiadis, Filippos |
collection | PubMed |
description | Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to heart failure (HF) development has been undermined in current clinical practice. This is because approximately half of HF patients have been labeled as suffering from HF with preserved left ventricular (LV) ejection fraction (EF) (HFpEF), with HTN, obesity, and diabetes mellitus (DM) being considered virtually equally responsible for its development. However, this suggestion is obviously inaccurate, since HTN is by far the most frequent and devastating morbidity present in HFpEF. Further, HF development in obesity or DM is rare in the absence of HTN or coronary artery disease (CAD), whereas HTN often causes HF per se. Finally, unlike HTN, for most major comorbidities present in HFpEF, including anemia, chronic kidney disease, pulmonary disease, DM, atrial fibrillation, sleep apnea, and depression, it is unknown whether they precede HF or result from it. The purpose of this paper is to provide a contemporary overview on hypertensive HF, with a special emphasis on its inflammatory nature and association with autonomic nervous system (ANS) imbalance, since both are of pathophysiologic and therapeutic interest. |
format | Online Article Text |
id | pubmed-10419453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104194532023-08-12 Hypertensive Heart Failure Triposkiadis, Filippos Sarafidis, Pantelis Briasoulis, Alexandros Magouliotis, Dimitrios E. Athanasiou, Thanos Skoularigis, John Xanthopoulos, Andrew J Clin Med Review Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to heart failure (HF) development has been undermined in current clinical practice. This is because approximately half of HF patients have been labeled as suffering from HF with preserved left ventricular (LV) ejection fraction (EF) (HFpEF), with HTN, obesity, and diabetes mellitus (DM) being considered virtually equally responsible for its development. However, this suggestion is obviously inaccurate, since HTN is by far the most frequent and devastating morbidity present in HFpEF. Further, HF development in obesity or DM is rare in the absence of HTN or coronary artery disease (CAD), whereas HTN often causes HF per se. Finally, unlike HTN, for most major comorbidities present in HFpEF, including anemia, chronic kidney disease, pulmonary disease, DM, atrial fibrillation, sleep apnea, and depression, it is unknown whether they precede HF or result from it. The purpose of this paper is to provide a contemporary overview on hypertensive HF, with a special emphasis on its inflammatory nature and association with autonomic nervous system (ANS) imbalance, since both are of pathophysiologic and therapeutic interest. MDPI 2023-08-02 /pmc/articles/PMC10419453/ /pubmed/37568493 http://dx.doi.org/10.3390/jcm12155090 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Triposkiadis, Filippos Sarafidis, Pantelis Briasoulis, Alexandros Magouliotis, Dimitrios E. Athanasiou, Thanos Skoularigis, John Xanthopoulos, Andrew Hypertensive Heart Failure |
title | Hypertensive Heart Failure |
title_full | Hypertensive Heart Failure |
title_fullStr | Hypertensive Heart Failure |
title_full_unstemmed | Hypertensive Heart Failure |
title_short | Hypertensive Heart Failure |
title_sort | hypertensive heart failure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419453/ https://www.ncbi.nlm.nih.gov/pubmed/37568493 http://dx.doi.org/10.3390/jcm12155090 |
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