Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B1...

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Detalles Bibliográficos
Autores principales: De Vita, Daniela, Frezza, Claudio, Sciubba, Fabio, Toniolo, Chiara, Badiali, Camilla, Petrucci, Rita, Bortolami, Martina, Di Matteo, Paola, Rocco, Daniele, Stringaro, Annarita, Colone, Marisa, Maxia, Andrea, Petrucci, Maria Teresa, Serafini, Mauro, Foddai, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419533/
https://www.ncbi.nlm.nih.gov/pubmed/37570609
http://dx.doi.org/10.3390/molecules28155639
Descripción
Sumario:Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.

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