Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B1...

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Autores principales: De Vita, Daniela, Frezza, Claudio, Sciubba, Fabio, Toniolo, Chiara, Badiali, Camilla, Petrucci, Rita, Bortolami, Martina, Di Matteo, Paola, Rocco, Daniele, Stringaro, Annarita, Colone, Marisa, Maxia, Andrea, Petrucci, Maria Teresa, Serafini, Mauro, Foddai, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419533/
https://www.ncbi.nlm.nih.gov/pubmed/37570609
http://dx.doi.org/10.3390/molecules28155639
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author De Vita, Daniela
Frezza, Claudio
Sciubba, Fabio
Toniolo, Chiara
Badiali, Camilla
Petrucci, Rita
Bortolami, Martina
Di Matteo, Paola
Rocco, Daniele
Stringaro, Annarita
Colone, Marisa
Maxia, Andrea
Petrucci, Maria Teresa
Serafini, Mauro
Foddai, Sebastiano
author_facet De Vita, Daniela
Frezza, Claudio
Sciubba, Fabio
Toniolo, Chiara
Badiali, Camilla
Petrucci, Rita
Bortolami, Martina
Di Matteo, Paola
Rocco, Daniele
Stringaro, Annarita
Colone, Marisa
Maxia, Andrea
Petrucci, Maria Teresa
Serafini, Mauro
Foddai, Sebastiano
author_sort De Vita, Daniela
collection PubMed
description Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
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spelling pubmed-104195332023-08-12 Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti De Vita, Daniela Frezza, Claudio Sciubba, Fabio Toniolo, Chiara Badiali, Camilla Petrucci, Rita Bortolami, Martina Di Matteo, Paola Rocco, Daniele Stringaro, Annarita Colone, Marisa Maxia, Andrea Petrucci, Maria Teresa Serafini, Mauro Foddai, Sebastiano Molecules Communication Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations. MDPI 2023-07-25 /pmc/articles/PMC10419533/ /pubmed/37570609 http://dx.doi.org/10.3390/molecules28155639 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
De Vita, Daniela
Frezza, Claudio
Sciubba, Fabio
Toniolo, Chiara
Badiali, Camilla
Petrucci, Rita
Bortolami, Martina
Di Matteo, Paola
Rocco, Daniele
Stringaro, Annarita
Colone, Marisa
Maxia, Andrea
Petrucci, Maria Teresa
Serafini, Mauro
Foddai, Sebastiano
Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title_full Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title_fullStr Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title_full_unstemmed Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title_short Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
title_sort phytochemical analysis and in vitro antileukemic activity of alkaloid-enriched extracts from vinca sardoa (stearn) pignatti
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419533/
https://www.ncbi.nlm.nih.gov/pubmed/37570609
http://dx.doi.org/10.3390/molecules28155639
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