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Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination

Cannabis can be related to respiratory diseases, but the relationship between smoking marijuana and the development of a pneumothorax has scarcely been investigated. We aimed to analyze, in patients with a history of cannabis smoking abuse submitted to lung apicectomy for a primary spontaneous pneum...

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Autores principales: Bisconti, Mario, De Palma, Angela, Pacifici, Roberta, Rotolo, Maria Concetta, Pichini, Simona, Brascia, Debora, Trabucco, Xenia, Pellegrini, Manuela, Carrozzi, Laura, Pistelli, Francesco, Marulli, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419578/
https://www.ncbi.nlm.nih.gov/pubmed/37568358
http://dx.doi.org/10.3390/jcm12154956
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author Bisconti, Mario
De Palma, Angela
Pacifici, Roberta
Rotolo, Maria Concetta
Pichini, Simona
Brascia, Debora
Trabucco, Xenia
Pellegrini, Manuela
Carrozzi, Laura
Pistelli, Francesco
Marulli, Giuseppe
author_facet Bisconti, Mario
De Palma, Angela
Pacifici, Roberta
Rotolo, Maria Concetta
Pichini, Simona
Brascia, Debora
Trabucco, Xenia
Pellegrini, Manuela
Carrozzi, Laura
Pistelli, Francesco
Marulli, Giuseppe
author_sort Bisconti, Mario
collection PubMed
description Cannabis can be related to respiratory diseases, but the relationship between smoking marijuana and the development of a pneumothorax has scarcely been investigated. We aimed to analyze, in patients with a history of cannabis smoking abuse submitted to lung apicectomy for a primary spontaneous pneumothorax (PSP), the correlation between the presence of cannabinoids in the resected lung and the detection of bullous emphysema within the same tissue. Patients undergoing lung apicectomy for a PSP were prospectively enrolled, and the correlation between the presence of cannabinoids in the resected lung tissue and histological finding of bullous emphysema was investigated with Fisher’s exact test. There were 21 male patients, with a median age of 27 years. The cannabinoids found by the toxicological examination in surgical specimens were mainly delta-9-tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD). In 14/21 patients, cannabinoids were detected in the resected lung tissue, and bullous emphysema was present in 13/14 of these (93%), while bullous emphysema was found in only 1/7 (14%) of the remaining patients who were negative for cannabinoids in the lung tissue, and the difference was found to be statistically significant (p < 0.0009). Our study demonstrated the presence of bullous emphysema in most cannabinoid-positive patients and its absence in most of those who were cannabinoid-negative, supporting the correlation between cannabinoids in the lung tissue and bullous emphysema with the development of a “secondary” spontaneous pneumothorax.
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spelling pubmed-104195782023-08-12 Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination Bisconti, Mario De Palma, Angela Pacifici, Roberta Rotolo, Maria Concetta Pichini, Simona Brascia, Debora Trabucco, Xenia Pellegrini, Manuela Carrozzi, Laura Pistelli, Francesco Marulli, Giuseppe J Clin Med Article Cannabis can be related to respiratory diseases, but the relationship between smoking marijuana and the development of a pneumothorax has scarcely been investigated. We aimed to analyze, in patients with a history of cannabis smoking abuse submitted to lung apicectomy for a primary spontaneous pneumothorax (PSP), the correlation between the presence of cannabinoids in the resected lung and the detection of bullous emphysema within the same tissue. Patients undergoing lung apicectomy for a PSP were prospectively enrolled, and the correlation between the presence of cannabinoids in the resected lung tissue and histological finding of bullous emphysema was investigated with Fisher’s exact test. There were 21 male patients, with a median age of 27 years. The cannabinoids found by the toxicological examination in surgical specimens were mainly delta-9-tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD). In 14/21 patients, cannabinoids were detected in the resected lung tissue, and bullous emphysema was present in 13/14 of these (93%), while bullous emphysema was found in only 1/7 (14%) of the remaining patients who were negative for cannabinoids in the lung tissue, and the difference was found to be statistically significant (p < 0.0009). Our study demonstrated the presence of bullous emphysema in most cannabinoid-positive patients and its absence in most of those who were cannabinoid-negative, supporting the correlation between cannabinoids in the lung tissue and bullous emphysema with the development of a “secondary” spontaneous pneumothorax. MDPI 2023-07-28 /pmc/articles/PMC10419578/ /pubmed/37568358 http://dx.doi.org/10.3390/jcm12154956 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bisconti, Mario
De Palma, Angela
Pacifici, Roberta
Rotolo, Maria Concetta
Pichini, Simona
Brascia, Debora
Trabucco, Xenia
Pellegrini, Manuela
Carrozzi, Laura
Pistelli, Francesco
Marulli, Giuseppe
Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title_full Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title_fullStr Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title_full_unstemmed Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title_short Spontaneous Pneumothorax Secondary to Bullous Lung Emphysema Positive for Cannabinoids upon Toxicological Examination
title_sort spontaneous pneumothorax secondary to bullous lung emphysema positive for cannabinoids upon toxicological examination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419578/
https://www.ncbi.nlm.nih.gov/pubmed/37568358
http://dx.doi.org/10.3390/jcm12154956
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