Cargando…

Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis

Introduction: Studies comparing male and female patients with abdominal aortic aneurysms have shown that female patients are generally older and more often experience postoperative complications after endovascular and open repair. There are also indications that female patients have more extensive n...

Descripción completa

Detalles Bibliográficos
Autores principales: Özdemir-van Brunschot, Denise Michelle Danielle, Holzhey, David, Botsios, Spiridon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419678/
https://www.ncbi.nlm.nih.gov/pubmed/37568333
http://dx.doi.org/10.3390/jcm12154929
_version_ 1785088583113113600
author Özdemir-van Brunschot, Denise Michelle Danielle
Holzhey, David
Botsios, Spiridon
author_facet Özdemir-van Brunschot, Denise Michelle Danielle
Holzhey, David
Botsios, Spiridon
author_sort Özdemir-van Brunschot, Denise Michelle Danielle
collection PubMed
description Introduction: Studies comparing male and female patients with abdominal aortic aneurysms have shown that female patients are generally older and more often experience postoperative complications after endovascular and open repair. There are also indications that female patients have more extensive neck pathologies and that they more often have postoperative complications related to proximal neck pathology. Material and methods: This retrospective study describes all consecutive female patients who underwent EVAR between 1 January 2012 and 31 December 2021. Propensity-score matching was used to obtain a matched control male cohort. Propensity scores were generated with the following anatomic parameters: infrarenal and suprarenal angulation, proximal and distal neck diameter and neck length. 1 Female patient was matched with 3 male patients. Results: A total of 160 patients were included, namely 120 male patients and 40 female patients. Due to matching, there were no significant differences regarding infrarenal and suprarenal angulation and proximal and distal neck diameter and length. All-cause and aneurysm-related mortality were comparable (p = 0.19 and p = 0.98). The necessity of neck-related secondary procedures was significantly higher in female patients (p = 0.02). In the multivariate analysis, the female sex was a significant predictor of endoleak type IA within 30 days. However, there was no significant association between intraoperative endoleak type IA and endoleak type IA at the end of follow-up. Conclusions: This study suggests that there was a higher initial incidence of endoleak type IA in female patients, despite thematched preoperative anatomic parameter. Due to the relatively low number of included female patients, conclusions should be drawn carefully.
format Online
Article
Text
id pubmed-10419678
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104196782023-08-12 Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis Özdemir-van Brunschot, Denise Michelle Danielle Holzhey, David Botsios, Spiridon J Clin Med Article Introduction: Studies comparing male and female patients with abdominal aortic aneurysms have shown that female patients are generally older and more often experience postoperative complications after endovascular and open repair. There are also indications that female patients have more extensive neck pathologies and that they more often have postoperative complications related to proximal neck pathology. Material and methods: This retrospective study describes all consecutive female patients who underwent EVAR between 1 January 2012 and 31 December 2021. Propensity-score matching was used to obtain a matched control male cohort. Propensity scores were generated with the following anatomic parameters: infrarenal and suprarenal angulation, proximal and distal neck diameter and neck length. 1 Female patient was matched with 3 male patients. Results: A total of 160 patients were included, namely 120 male patients and 40 female patients. Due to matching, there were no significant differences regarding infrarenal and suprarenal angulation and proximal and distal neck diameter and length. All-cause and aneurysm-related mortality were comparable (p = 0.19 and p = 0.98). The necessity of neck-related secondary procedures was significantly higher in female patients (p = 0.02). In the multivariate analysis, the female sex was a significant predictor of endoleak type IA within 30 days. However, there was no significant association between intraoperative endoleak type IA and endoleak type IA at the end of follow-up. Conclusions: This study suggests that there was a higher initial incidence of endoleak type IA in female patients, despite thematched preoperative anatomic parameter. Due to the relatively low number of included female patients, conclusions should be drawn carefully. MDPI 2023-07-27 /pmc/articles/PMC10419678/ /pubmed/37568333 http://dx.doi.org/10.3390/jcm12154929 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Özdemir-van Brunschot, Denise Michelle Danielle
Holzhey, David
Botsios, Spiridon
Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title_full Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title_fullStr Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title_full_unstemmed Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title_short Sex-Related Differences in Proximal Neck Anatomy and Their Consequences in Patients after EVAR: A Matched Cohort Analysis
title_sort sex-related differences in proximal neck anatomy and their consequences in patients after evar: a matched cohort analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419678/
https://www.ncbi.nlm.nih.gov/pubmed/37568333
http://dx.doi.org/10.3390/jcm12154929
work_keys_str_mv AT ozdemirvanbrunschotdenisemichelledanielle sexrelateddifferencesinproximalneckanatomyandtheirconsequencesinpatientsafterevaramatchedcohortanalysis
AT holzheydavid sexrelateddifferencesinproximalneckanatomyandtheirconsequencesinpatientsafterevaramatchedcohortanalysis
AT botsiosspiridon sexrelateddifferencesinproximalneckanatomyandtheirconsequencesinpatientsafterevaramatchedcohortanalysis