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Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419809/ https://www.ncbi.nlm.nih.gov/pubmed/37570108 http://dx.doi.org/10.3390/ma16155404 |
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author | Szczuka, Joanna Sandomierski, Mariusz Voelkel, Adam Grochalski, Karol Buchwald, Tomasz |
author_facet | Szczuka, Joanna Sandomierski, Mariusz Voelkel, Adam Grochalski, Karol Buchwald, Tomasz |
author_sort | Szczuka, Joanna |
collection | PubMed |
description | With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better—it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for H(2)O(2) solution. |
format | Online Article Text |
id | pubmed-10419809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104198092023-08-12 Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium Szczuka, Joanna Sandomierski, Mariusz Voelkel, Adam Grochalski, Karol Buchwald, Tomasz Materials (Basel) Article With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better—it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for H(2)O(2) solution. MDPI 2023-08-01 /pmc/articles/PMC10419809/ /pubmed/37570108 http://dx.doi.org/10.3390/ma16155404 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Szczuka, Joanna Sandomierski, Mariusz Voelkel, Adam Grochalski, Karol Buchwald, Tomasz Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title | Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title_full | Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title_fullStr | Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title_full_unstemmed | Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title_short | Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium |
title_sort | surface modification of ti6al4v eli titanium alloy by poly(ethylene-alt-maleic anhydride) and risedronate sodium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419809/ https://www.ncbi.nlm.nih.gov/pubmed/37570108 http://dx.doi.org/10.3390/ma16155404 |
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