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Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium

With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery....

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Autores principales: Szczuka, Joanna, Sandomierski, Mariusz, Voelkel, Adam, Grochalski, Karol, Buchwald, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419809/
https://www.ncbi.nlm.nih.gov/pubmed/37570108
http://dx.doi.org/10.3390/ma16155404
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author Szczuka, Joanna
Sandomierski, Mariusz
Voelkel, Adam
Grochalski, Karol
Buchwald, Tomasz
author_facet Szczuka, Joanna
Sandomierski, Mariusz
Voelkel, Adam
Grochalski, Karol
Buchwald, Tomasz
author_sort Szczuka, Joanna
collection PubMed
description With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better—it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for H(2)O(2) solution.
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spelling pubmed-104198092023-08-12 Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium Szczuka, Joanna Sandomierski, Mariusz Voelkel, Adam Grochalski, Karol Buchwald, Tomasz Materials (Basel) Article With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better—it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for H(2)O(2) solution. MDPI 2023-08-01 /pmc/articles/PMC10419809/ /pubmed/37570108 http://dx.doi.org/10.3390/ma16155404 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szczuka, Joanna
Sandomierski, Mariusz
Voelkel, Adam
Grochalski, Karol
Buchwald, Tomasz
Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title_full Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title_fullStr Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title_full_unstemmed Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title_short Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium
title_sort surface modification of ti6al4v eli titanium alloy by poly(ethylene-alt-maleic anhydride) and risedronate sodium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419809/
https://www.ncbi.nlm.nih.gov/pubmed/37570108
http://dx.doi.org/10.3390/ma16155404
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