Cargando…
Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance
This study aimed to evaluate foveal avascular zone (FAZ) features and macular flow density (FD) in various retinal layers in a cohort of patients with foveal hypoplasia (FH) using optical coherence tomography angiography (OCTA), in order to characterize microvascular abnormalities and explore their...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419931/ https://www.ncbi.nlm.nih.gov/pubmed/37568394 http://dx.doi.org/10.3390/jcm12154992 |
_version_ | 1785088649232121856 |
---|---|
author | Storp, Jens Julian Zimmermann, Julian Alexander Danzer, Moritz Fabian Alnawaiseh, Maged Eter, Nicole Al-Nawaiseh, Sami |
author_facet | Storp, Jens Julian Zimmermann, Julian Alexander Danzer, Moritz Fabian Alnawaiseh, Maged Eter, Nicole Al-Nawaiseh, Sami |
author_sort | Storp, Jens Julian |
collection | PubMed |
description | This study aimed to evaluate foveal avascular zone (FAZ) features and macular flow density (FD) in various retinal layers in a cohort of patients with foveal hypoplasia (FH) using optical coherence tomography angiography (OCTA), in order to characterize microvascular abnormalities and explore their potential clinical significance. FAZ parameters and FD, as well as retinal thickness and volume values were analyzed and compared between patients with FH and an age- and gender-matched control cohort. Correlations between disease severity and visual acuity (VA), as well as between disease severity and FAZ features were evaluated. A total of 19 eyes with FH and 19 control eyes were included. The study group showed significantly higher FD values in the foveal sectors of the superficial and deep capillary plexus compared to controls. FAZ area, perimeter, and acircularity index (ACI) were noticeably altered in eyes with FH; however, they did not correlate with disease severity. Visual acuity was negatively correlated with disease severity. The results of this study provide evidence of altered microvasculature architecture specifically in the foveal sectors of patients with FH. The higher FD values in the foveal sectors of FH patients suggest a potential compensatory response of the retinal microvasculature. FAZ parameters and FD values of the foveal sectors could be used as part of an OCTA-based grading system in FH patients. |
format | Online Article Text |
id | pubmed-10419931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104199312023-08-12 Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance Storp, Jens Julian Zimmermann, Julian Alexander Danzer, Moritz Fabian Alnawaiseh, Maged Eter, Nicole Al-Nawaiseh, Sami J Clin Med Article This study aimed to evaluate foveal avascular zone (FAZ) features and macular flow density (FD) in various retinal layers in a cohort of patients with foveal hypoplasia (FH) using optical coherence tomography angiography (OCTA), in order to characterize microvascular abnormalities and explore their potential clinical significance. FAZ parameters and FD, as well as retinal thickness and volume values were analyzed and compared between patients with FH and an age- and gender-matched control cohort. Correlations between disease severity and visual acuity (VA), as well as between disease severity and FAZ features were evaluated. A total of 19 eyes with FH and 19 control eyes were included. The study group showed significantly higher FD values in the foveal sectors of the superficial and deep capillary plexus compared to controls. FAZ area, perimeter, and acircularity index (ACI) were noticeably altered in eyes with FH; however, they did not correlate with disease severity. Visual acuity was negatively correlated with disease severity. The results of this study provide evidence of altered microvasculature architecture specifically in the foveal sectors of patients with FH. The higher FD values in the foveal sectors of FH patients suggest a potential compensatory response of the retinal microvasculature. FAZ parameters and FD values of the foveal sectors could be used as part of an OCTA-based grading system in FH patients. MDPI 2023-07-29 /pmc/articles/PMC10419931/ /pubmed/37568394 http://dx.doi.org/10.3390/jcm12154992 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Storp, Jens Julian Zimmermann, Julian Alexander Danzer, Moritz Fabian Alnawaiseh, Maged Eter, Nicole Al-Nawaiseh, Sami Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title | Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title_full | Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title_fullStr | Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title_full_unstemmed | Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title_short | Characterizing Foveal Hypoplasia Using Optical Coherence Tomography Angiography: Evaluation of Microvascular Abnormalities and Clinical Significance |
title_sort | characterizing foveal hypoplasia using optical coherence tomography angiography: evaluation of microvascular abnormalities and clinical significance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419931/ https://www.ncbi.nlm.nih.gov/pubmed/37568394 http://dx.doi.org/10.3390/jcm12154992 |
work_keys_str_mv | AT storpjensjulian characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance AT zimmermannjulianalexander characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance AT danzermoritzfabian characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance AT alnawaisehmaged characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance AT eternicole characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance AT alnawaisehsami characterizingfovealhypoplasiausingopticalcoherencetomographyangiographyevaluationofmicrovascularabnormalitiesandclinicalsignificance |