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A Sustainable Green Enzymatic Method for Amide Bond Formation
A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the nee...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419938/ https://www.ncbi.nlm.nih.gov/pubmed/37570676 http://dx.doi.org/10.3390/molecules28155706 |
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author | Orsy, György Shahmohammadi, Sayeh Forró, Enikő |
author_facet | Orsy, György Shahmohammadi, Sayeh Forró, Enikő |
author_sort | Orsy, György |
collection | PubMed |
description | A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. |
format | Online Article Text |
id | pubmed-10419938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104199382023-08-12 A Sustainable Green Enzymatic Method for Amide Bond Formation Orsy, György Shahmohammadi, Sayeh Forró, Enikő Molecules Article A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. MDPI 2023-07-28 /pmc/articles/PMC10419938/ /pubmed/37570676 http://dx.doi.org/10.3390/molecules28155706 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Orsy, György Shahmohammadi, Sayeh Forró, Enikő A Sustainable Green Enzymatic Method for Amide Bond Formation |
title | A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_full | A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_fullStr | A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_full_unstemmed | A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_short | A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_sort | sustainable green enzymatic method for amide bond formation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419938/ https://www.ncbi.nlm.nih.gov/pubmed/37570676 http://dx.doi.org/10.3390/molecules28155706 |
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