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A Sustainable Green Enzymatic Method for Amide Bond Formation

A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the nee...

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Autores principales: Orsy, György, Shahmohammadi, Sayeh, Forró, Enikő
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419938/
https://www.ncbi.nlm.nih.gov/pubmed/37570676
http://dx.doi.org/10.3390/molecules28155706
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author Orsy, György
Shahmohammadi, Sayeh
Forró, Enikő
author_facet Orsy, György
Shahmohammadi, Sayeh
Forró, Enikő
author_sort Orsy, György
collection PubMed
description A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis.
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spelling pubmed-104199382023-08-12 A Sustainable Green Enzymatic Method for Amide Bond Formation Orsy, György Shahmohammadi, Sayeh Forró, Enikő Molecules Article A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. MDPI 2023-07-28 /pmc/articles/PMC10419938/ /pubmed/37570676 http://dx.doi.org/10.3390/molecules28155706 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Orsy, György
Shahmohammadi, Sayeh
Forró, Enikő
A Sustainable Green Enzymatic Method for Amide Bond Formation
title A Sustainable Green Enzymatic Method for Amide Bond Formation
title_full A Sustainable Green Enzymatic Method for Amide Bond Formation
title_fullStr A Sustainable Green Enzymatic Method for Amide Bond Formation
title_full_unstemmed A Sustainable Green Enzymatic Method for Amide Bond Formation
title_short A Sustainable Green Enzymatic Method for Amide Bond Formation
title_sort sustainable green enzymatic method for amide bond formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419938/
https://www.ncbi.nlm.nih.gov/pubmed/37570676
http://dx.doi.org/10.3390/molecules28155706
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