Cargando…
Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis
(1) Background and Objectives: Transcatheter aortic valve implantation is guideline-recommended from the age of 75. However, this European guideline recommendation is based on limited evidence, since no interaction between age and primary outcome has been found in guideline-stated references. This s...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420005/ https://www.ncbi.nlm.nih.gov/pubmed/37568365 http://dx.doi.org/10.3390/jcm12154963 |
_version_ | 1785088668055109632 |
---|---|
author | Taghizadeh-Waghefi, Ali Petrov, Asen Jatzke, Philipp Wilbring, Manuel Kappert, Utz Matschke, Klaus Alexiou, Konstantin Arzt, Sebastian |
author_facet | Taghizadeh-Waghefi, Ali Petrov, Asen Jatzke, Philipp Wilbring, Manuel Kappert, Utz Matschke, Klaus Alexiou, Konstantin Arzt, Sebastian |
author_sort | Taghizadeh-Waghefi, Ali |
collection | PubMed |
description | (1) Background and Objectives: Transcatheter aortic valve implantation is guideline-recommended from the age of 75. However, this European guideline recommendation is based on limited evidence, since no interaction between age and primary outcome has been found in guideline-stated references. This study aimed to compare the short-term outcomes of minimally invasive isolated aortic valve replacement in patients aged ≥ 75 with those of younger patients; (2) Patients and Methods: This retrospective cohort study included 1339 patients who underwent minimally invasive isolated aortic valve replacement at our facility between 2014 and 2022. This cohort was divided into two age-based groups: <75 and ≥75 years. Operative morbidity and mortality were compared between groups. Further analysis was performed using propensity score matching; (3) Results: After matching, 347 pairs of patients were included and analyzed. Despite the higher EuroSCORE II in the ≥75 group (2.2 ± 1.3% vs. 1.80 ± 1.34%, p ≤ 0.001), the 30-day mortality (1.4% vs. 1.2%; p = 0.90) and major adverse cardiac and cerebrovascular events, such as perioperative myocardial infarction (0.0% vs. 1.2%, p = 0.12) and stroke (1.4% vs. 2.6%, p = 0.06), were comparable between both treatment groups; (4) Conclusions: Minimally invasive aortic valve replacement is a safe treatment method for patients aged ≥ 75. Our results indicate that the unilateral cut-off of 75 years is not a limiting factor for performing minimally invasive aortic valve replacement. |
format | Online Article Text |
id | pubmed-10420005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104200052023-08-12 Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis Taghizadeh-Waghefi, Ali Petrov, Asen Jatzke, Philipp Wilbring, Manuel Kappert, Utz Matschke, Klaus Alexiou, Konstantin Arzt, Sebastian J Clin Med Article (1) Background and Objectives: Transcatheter aortic valve implantation is guideline-recommended from the age of 75. However, this European guideline recommendation is based on limited evidence, since no interaction between age and primary outcome has been found in guideline-stated references. This study aimed to compare the short-term outcomes of minimally invasive isolated aortic valve replacement in patients aged ≥ 75 with those of younger patients; (2) Patients and Methods: This retrospective cohort study included 1339 patients who underwent minimally invasive isolated aortic valve replacement at our facility between 2014 and 2022. This cohort was divided into two age-based groups: <75 and ≥75 years. Operative morbidity and mortality were compared between groups. Further analysis was performed using propensity score matching; (3) Results: After matching, 347 pairs of patients were included and analyzed. Despite the higher EuroSCORE II in the ≥75 group (2.2 ± 1.3% vs. 1.80 ± 1.34%, p ≤ 0.001), the 30-day mortality (1.4% vs. 1.2%; p = 0.90) and major adverse cardiac and cerebrovascular events, such as perioperative myocardial infarction (0.0% vs. 1.2%, p = 0.12) and stroke (1.4% vs. 2.6%, p = 0.06), were comparable between both treatment groups; (4) Conclusions: Minimally invasive aortic valve replacement is a safe treatment method for patients aged ≥ 75. Our results indicate that the unilateral cut-off of 75 years is not a limiting factor for performing minimally invasive aortic valve replacement. MDPI 2023-07-28 /pmc/articles/PMC10420005/ /pubmed/37568365 http://dx.doi.org/10.3390/jcm12154963 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Taghizadeh-Waghefi, Ali Petrov, Asen Jatzke, Philipp Wilbring, Manuel Kappert, Utz Matschke, Klaus Alexiou, Konstantin Arzt, Sebastian Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title | Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title_full | Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title_fullStr | Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title_full_unstemmed | Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title_short | Minimally Invasive Isolated Aortic Valve Replacement in a Potential TAVI Cohort of Patients Aged ≥ 75 Years: A Propensity-Matched Analysis |
title_sort | minimally invasive isolated aortic valve replacement in a potential tavi cohort of patients aged ≥ 75 years: a propensity-matched analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420005/ https://www.ncbi.nlm.nih.gov/pubmed/37568365 http://dx.doi.org/10.3390/jcm12154963 |
work_keys_str_mv | AT taghizadehwaghefiali minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT petrovasen minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT jatzkephilipp minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT wilbringmanuel minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT kappertutz minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT matschkeklaus minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT alexioukonstantin minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis AT arztsebastian minimallyinvasiveisolatedaorticvalvereplacementinapotentialtavicohortofpatientsaged75yearsapropensitymatchedanalysis |