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Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis

Coagulation factor XI (FXI) promotes fibrin formation and inhibits fibrinolysis. Elevated plasma FXI levels, limited to a single measurement, are associated with a higher thrombotic risk. Our case–control study aimed to identify the effect of persistently increased plasma FXI levels on the risk of d...

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Autores principales: Spiezia, Luca, Forestan, Chiara, Campello, Elena, Simion, Chiara, Simioni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420025/
https://www.ncbi.nlm.nih.gov/pubmed/37568292
http://dx.doi.org/10.3390/jcm12154890
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author Spiezia, Luca
Forestan, Chiara
Campello, Elena
Simion, Chiara
Simioni, Paolo
author_facet Spiezia, Luca
Forestan, Chiara
Campello, Elena
Simion, Chiara
Simioni, Paolo
author_sort Spiezia, Luca
collection PubMed
description Coagulation factor XI (FXI) promotes fibrin formation and inhibits fibrinolysis. Elevated plasma FXI levels, limited to a single measurement, are associated with a higher thrombotic risk. Our case–control study aimed to identify the effect of persistently increased plasma FXI levels on the risk of deep vein thrombosis (DVT). All patients evaluated between January 2016 and January 2018 for a first episode of proximal DVT of the lower extremity were considered for enrolment. Plasma FXI levels were measured at least 1 month after the discontinuation of anticoagulant treatment (T1). The patients with increased plasma FXI levels (>90th percentile of controls) were tested again 3 months later (T2). Among the 200 enrolled patients (M/F 114/86, age range 26–87 years), 47 patients had increased plasma FXI levels at T1 and16 patients had persistently increased plasma FXI levels at T2. The adjusted odds ratio for DVT was 2.4 (95% CI, 1.3 to 5.5, p < 0.001) for patients with increased FXI levels at T1 and 5.2 (95% CI, 2.3 to 13.2, p < 0.001) for patients with persistently high FXI levels at T2. Elevated FXI levels constitute a risk factor for deep vein thrombosis, and this risk nearly doubled in patients with persistently increased plasma FXI levels. Larger prospective studies are needed to confirm our findings.
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spelling pubmed-104200252023-08-12 Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis Spiezia, Luca Forestan, Chiara Campello, Elena Simion, Chiara Simioni, Paolo J Clin Med Article Coagulation factor XI (FXI) promotes fibrin formation and inhibits fibrinolysis. Elevated plasma FXI levels, limited to a single measurement, are associated with a higher thrombotic risk. Our case–control study aimed to identify the effect of persistently increased plasma FXI levels on the risk of deep vein thrombosis (DVT). All patients evaluated between January 2016 and January 2018 for a first episode of proximal DVT of the lower extremity were considered for enrolment. Plasma FXI levels were measured at least 1 month after the discontinuation of anticoagulant treatment (T1). The patients with increased plasma FXI levels (>90th percentile of controls) were tested again 3 months later (T2). Among the 200 enrolled patients (M/F 114/86, age range 26–87 years), 47 patients had increased plasma FXI levels at T1 and16 patients had persistently increased plasma FXI levels at T2. The adjusted odds ratio for DVT was 2.4 (95% CI, 1.3 to 5.5, p < 0.001) for patients with increased FXI levels at T1 and 5.2 (95% CI, 2.3 to 13.2, p < 0.001) for patients with persistently high FXI levels at T2. Elevated FXI levels constitute a risk factor for deep vein thrombosis, and this risk nearly doubled in patients with persistently increased plasma FXI levels. Larger prospective studies are needed to confirm our findings. MDPI 2023-07-25 /pmc/articles/PMC10420025/ /pubmed/37568292 http://dx.doi.org/10.3390/jcm12154890 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spiezia, Luca
Forestan, Chiara
Campello, Elena
Simion, Chiara
Simioni, Paolo
Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title_full Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title_fullStr Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title_full_unstemmed Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title_short Persistently High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
title_sort persistently high levels of coagulation factor xi as a risk factor for venous thrombosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420025/
https://www.ncbi.nlm.nih.gov/pubmed/37568292
http://dx.doi.org/10.3390/jcm12154890
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