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The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420038/ https://www.ncbi.nlm.nih.gov/pubmed/37568504 http://dx.doi.org/10.3390/jcm12155102 |
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author | Hsieh, Chi-Chia Fu, Yi-Hsiu Ku, Nien-En Hsia, Chia-Chun Hung, Yu-Tung Hsu, Tzu-Ju Chen, Sung-Hsiung Kuo, Shu-Jui |
author_facet | Hsieh, Chi-Chia Fu, Yi-Hsiu Ku, Nien-En Hsia, Chia-Chun Hung, Yu-Tung Hsu, Tzu-Ju Chen, Sung-Hsiung Kuo, Shu-Jui |
author_sort | Hsieh, Chi-Chia |
collection | PubMed |
description | Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence (p < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2–3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients. |
format | Online Article Text |
id | pubmed-10420038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104200382023-08-12 The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data Hsieh, Chi-Chia Fu, Yi-Hsiu Ku, Nien-En Hsia, Chia-Chun Hung, Yu-Tung Hsu, Tzu-Ju Chen, Sung-Hsiung Kuo, Shu-Jui J Clin Med Article Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence (p < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2–3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients. MDPI 2023-08-03 /pmc/articles/PMC10420038/ /pubmed/37568504 http://dx.doi.org/10.3390/jcm12155102 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hsieh, Chi-Chia Fu, Yi-Hsiu Ku, Nien-En Hsia, Chia-Chun Hung, Yu-Tung Hsu, Tzu-Ju Chen, Sung-Hsiung Kuo, Shu-Jui The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title | The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title_full | The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title_fullStr | The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title_full_unstemmed | The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title_short | The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data |
title_sort | impact of chronic pancreatitis on the occurrences of human cancers: real-world data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420038/ https://www.ncbi.nlm.nih.gov/pubmed/37568504 http://dx.doi.org/10.3390/jcm12155102 |
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