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The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data

Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 2...

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Autores principales: Hsieh, Chi-Chia, Fu, Yi-Hsiu, Ku, Nien-En, Hsia, Chia-Chun, Hung, Yu-Tung, Hsu, Tzu-Ju, Chen, Sung-Hsiung, Kuo, Shu-Jui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420038/
https://www.ncbi.nlm.nih.gov/pubmed/37568504
http://dx.doi.org/10.3390/jcm12155102
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author Hsieh, Chi-Chia
Fu, Yi-Hsiu
Ku, Nien-En
Hsia, Chia-Chun
Hung, Yu-Tung
Hsu, Tzu-Ju
Chen, Sung-Hsiung
Kuo, Shu-Jui
author_facet Hsieh, Chi-Chia
Fu, Yi-Hsiu
Ku, Nien-En
Hsia, Chia-Chun
Hung, Yu-Tung
Hsu, Tzu-Ju
Chen, Sung-Hsiung
Kuo, Shu-Jui
author_sort Hsieh, Chi-Chia
collection PubMed
description Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence (p < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2–3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients.
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spelling pubmed-104200382023-08-12 The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data Hsieh, Chi-Chia Fu, Yi-Hsiu Ku, Nien-En Hsia, Chia-Chun Hung, Yu-Tung Hsu, Tzu-Ju Chen, Sung-Hsiung Kuo, Shu-Jui J Clin Med Article Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence (p < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2–3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients. MDPI 2023-08-03 /pmc/articles/PMC10420038/ /pubmed/37568504 http://dx.doi.org/10.3390/jcm12155102 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsieh, Chi-Chia
Fu, Yi-Hsiu
Ku, Nien-En
Hsia, Chia-Chun
Hung, Yu-Tung
Hsu, Tzu-Ju
Chen, Sung-Hsiung
Kuo, Shu-Jui
The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title_full The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title_fullStr The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title_full_unstemmed The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title_short The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data
title_sort impact of chronic pancreatitis on the occurrences of human cancers: real-world data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420038/
https://www.ncbi.nlm.nih.gov/pubmed/37568504
http://dx.doi.org/10.3390/jcm12155102
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