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Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity

Plant synthetic biology has emerged as a powerful and promising approach to enhance the production of value-added metabolites in plants. Flavonoids, a class of plant secondary metabolites, offer numerous health benefits and have attracted attention for their potential use in plant-based products. Ho...

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Autores principales: Jiang, Lina, Gao, Yifei, Han, Leiqin, Zhang, Wenxuan, Fan, Pengxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420081/
https://www.ncbi.nlm.nih.gov/pubmed/37575923
http://dx.doi.org/10.3389/fpls.2023.1220062
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author Jiang, Lina
Gao, Yifei
Han, Leiqin
Zhang, Wenxuan
Fan, Pengxiang
author_facet Jiang, Lina
Gao, Yifei
Han, Leiqin
Zhang, Wenxuan
Fan, Pengxiang
author_sort Jiang, Lina
collection PubMed
description Plant synthetic biology has emerged as a powerful and promising approach to enhance the production of value-added metabolites in plants. Flavonoids, a class of plant secondary metabolites, offer numerous health benefits and have attracted attention for their potential use in plant-based products. However, achieving high yields of specific flavonoids remains challenging due to the complex and diverse metabolic pathways involved in their biosynthesis. In recent years, synthetic biology approaches leveraging transcription factors and enzyme diversity have demonstrated promise in enhancing flavonoid yields and expanding their production repertoire. This review delves into the latest research progress in flavonoid metabolic engineering, encompassing the identification and manipulation of transcription factors and enzymes involved in flavonoid biosynthesis, as well as the deployment of synthetic biology tools for designing metabolic pathways. This review underscores the importance of employing carefully-selected transcription factors to boost plant flavonoid production and harnessing enzyme promiscuity to broaden flavonoid diversity or streamline the biosynthetic steps required for effective metabolic engineering. By harnessing the power of synthetic biology and a deeper understanding of flavonoid biosynthesis, future researchers can potentially transform the landscape of plant-based product development across the food and beverage, pharmaceutical, and cosmetic industries, ultimately benefiting consumers worldwide.
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spelling pubmed-104200812023-08-12 Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity Jiang, Lina Gao, Yifei Han, Leiqin Zhang, Wenxuan Fan, Pengxiang Front Plant Sci Plant Science Plant synthetic biology has emerged as a powerful and promising approach to enhance the production of value-added metabolites in plants. Flavonoids, a class of plant secondary metabolites, offer numerous health benefits and have attracted attention for their potential use in plant-based products. However, achieving high yields of specific flavonoids remains challenging due to the complex and diverse metabolic pathways involved in their biosynthesis. In recent years, synthetic biology approaches leveraging transcription factors and enzyme diversity have demonstrated promise in enhancing flavonoid yields and expanding their production repertoire. This review delves into the latest research progress in flavonoid metabolic engineering, encompassing the identification and manipulation of transcription factors and enzymes involved in flavonoid biosynthesis, as well as the deployment of synthetic biology tools for designing metabolic pathways. This review underscores the importance of employing carefully-selected transcription factors to boost plant flavonoid production and harnessing enzyme promiscuity to broaden flavonoid diversity or streamline the biosynthetic steps required for effective metabolic engineering. By harnessing the power of synthetic biology and a deeper understanding of flavonoid biosynthesis, future researchers can potentially transform the landscape of plant-based product development across the food and beverage, pharmaceutical, and cosmetic industries, ultimately benefiting consumers worldwide. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10420081/ /pubmed/37575923 http://dx.doi.org/10.3389/fpls.2023.1220062 Text en Copyright © 2023 Jiang, Gao, Han, Zhang and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Jiang, Lina
Gao, Yifei
Han, Leiqin
Zhang, Wenxuan
Fan, Pengxiang
Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title_full Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title_fullStr Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title_full_unstemmed Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title_short Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
title_sort designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420081/
https://www.ncbi.nlm.nih.gov/pubmed/37575923
http://dx.doi.org/10.3389/fpls.2023.1220062
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