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Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia

(1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identif...

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Autores principales: Kaszczewska, Monika, Chudziński, Witold, Kaszczewski, Piotr, Popow, Michał, Grzybowski, Jakub, Skowrońska-Szcześniak, Anna, Kozubek, Herbert, Gałązka, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420109/
https://www.ncbi.nlm.nih.gov/pubmed/37568342
http://dx.doi.org/10.3390/jcm12154939
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author Kaszczewska, Monika
Chudziński, Witold
Kaszczewski, Piotr
Popow, Michał
Grzybowski, Jakub
Skowrońska-Szcześniak, Anna
Kozubek, Herbert
Gałązka, Zbigniew
author_facet Kaszczewska, Monika
Chudziński, Witold
Kaszczewski, Piotr
Popow, Michał
Grzybowski, Jakub
Skowrońska-Szcześniak, Anna
Kozubek, Herbert
Gałązka, Zbigniew
author_sort Kaszczewska, Monika
collection PubMed
description (1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identify risk factors for severe hypercalcemia; (2) Methods: A total of 17 patients with PHPT and parathyroid cysts (study group) were compared with the group of 100 patients with hyperparathyroidism caused by adenoma or hyperplasia (control group). In both groups the majority were women (88% vs. 12%, with gender ratio 7, 3:1). The patients were examined preoperatively and postoperatively: PTH, creatine, calcium and phosphate serum and urine concentrations and calcidiol serum levels were assessed; (3) Results: Patients with parathyroid cyst had statistically higher PTH and calcium serum concentration, higher calciuria and lower serum phosphate concentration. There were no statistically significant differences in the concentration of creatine in serum and urine and tubular reabsorption of phosphorus (TRP); (4) Conclusions: Due to higher PTH and calcium levels, cystic parathyroid adenomas could be one of the rare risk factors for severe hypercalcemia and hypercalcemic crisis which can be life threatening.
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spelling pubmed-104201092023-08-12 Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia Kaszczewska, Monika Chudziński, Witold Kaszczewski, Piotr Popow, Michał Grzybowski, Jakub Skowrońska-Szcześniak, Anna Kozubek, Herbert Gałązka, Zbigniew J Clin Med Article (1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identify risk factors for severe hypercalcemia; (2) Methods: A total of 17 patients with PHPT and parathyroid cysts (study group) were compared with the group of 100 patients with hyperparathyroidism caused by adenoma or hyperplasia (control group). In both groups the majority were women (88% vs. 12%, with gender ratio 7, 3:1). The patients were examined preoperatively and postoperatively: PTH, creatine, calcium and phosphate serum and urine concentrations and calcidiol serum levels were assessed; (3) Results: Patients with parathyroid cyst had statistically higher PTH and calcium serum concentration, higher calciuria and lower serum phosphate concentration. There were no statistically significant differences in the concentration of creatine in serum and urine and tubular reabsorption of phosphorus (TRP); (4) Conclusions: Due to higher PTH and calcium levels, cystic parathyroid adenomas could be one of the rare risk factors for severe hypercalcemia and hypercalcemic crisis which can be life threatening. MDPI 2023-07-27 /pmc/articles/PMC10420109/ /pubmed/37568342 http://dx.doi.org/10.3390/jcm12154939 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaszczewska, Monika
Chudziński, Witold
Kaszczewski, Piotr
Popow, Michał
Grzybowski, Jakub
Skowrońska-Szcześniak, Anna
Kozubek, Herbert
Gałązka, Zbigniew
Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title_full Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title_fullStr Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title_full_unstemmed Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title_short Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
title_sort cystic parathyroid adenomas as a risk factor for severe hypercalcemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420109/
https://www.ncbi.nlm.nih.gov/pubmed/37568342
http://dx.doi.org/10.3390/jcm12154939
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