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Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review

Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological...

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Autores principales: Danpanichkul, Pojsakorn, Suparan, Kanokphong, Arayakarnkul, Suchapa, Jaroenlapnopparat, Aunchalee, Polpichai, Natchaya, Fangsaard, Panisara, Kongarin, Siwanart, Srisurapanont, Karan, Sukphutanan, Banthoon, Wanchaitanawong, Wasuwit, Kanjanakot, Yatawee, Pupaibool, Jakrapun, Duangsonk, Kwanjit, Kochhar, Gursimran Singh, Wijarnpreecha, Karn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420121/
https://www.ncbi.nlm.nih.gov/pubmed/37568544
http://dx.doi.org/10.3390/jcm12155142
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author Danpanichkul, Pojsakorn
Suparan, Kanokphong
Arayakarnkul, Suchapa
Jaroenlapnopparat, Aunchalee
Polpichai, Natchaya
Fangsaard, Panisara
Kongarin, Siwanart
Srisurapanont, Karan
Sukphutanan, Banthoon
Wanchaitanawong, Wasuwit
Kanjanakot, Yatawee
Pupaibool, Jakrapun
Duangsonk, Kwanjit
Kochhar, Gursimran Singh
Wijarnpreecha, Karn
author_facet Danpanichkul, Pojsakorn
Suparan, Kanokphong
Arayakarnkul, Suchapa
Jaroenlapnopparat, Aunchalee
Polpichai, Natchaya
Fangsaard, Panisara
Kongarin, Siwanart
Srisurapanont, Karan
Sukphutanan, Banthoon
Wanchaitanawong, Wasuwit
Kanjanakot, Yatawee
Pupaibool, Jakrapun
Duangsonk, Kwanjit
Kochhar, Gursimran Singh
Wijarnpreecha, Karn
author_sort Danpanichkul, Pojsakorn
collection PubMed
description Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological data regarding elderly-onset IBD are currently insufficient. Our study addresses this critical gap by analyzing trends in elderly-onset IBD over a decade, encompassing the estimation of annual frequencies and age-standardized rates of elderly-onset IBD burden for both genders, stratifying the data by geographical and sociodemographic factors. Our research highlights a notable increase in the proportion of elderly-onset IBD, constituting around 13% of all IBD cases. We observed a rising incidence in males, contrasted by a decreasing trend in females. The highest surge in incidence rates was seen in the Western Pacific region in both genders, but the highest burden was observed in America. Countries with high sociodemographic index (SDI) carried the greatest burden of elderly-onset IBD, while countries with low SDI had the least. The mortality and disability-adjusted life years (DALYs) rates trend downward in most regions. This study underscores an increasing incidence and proportion of IBD, particularly in elderly-onset IBD, particularly in males. While mortality and DALYs are decreasing in most regions, the overall burden remains highest in America and high-SDI countries. Effective public health interventions and comprehensive studies are required to tackle this mounting burden.
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spelling pubmed-104201212023-08-12 Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review Danpanichkul, Pojsakorn Suparan, Kanokphong Arayakarnkul, Suchapa Jaroenlapnopparat, Aunchalee Polpichai, Natchaya Fangsaard, Panisara Kongarin, Siwanart Srisurapanont, Karan Sukphutanan, Banthoon Wanchaitanawong, Wasuwit Kanjanakot, Yatawee Pupaibool, Jakrapun Duangsonk, Kwanjit Kochhar, Gursimran Singh Wijarnpreecha, Karn J Clin Med Article Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological data regarding elderly-onset IBD are currently insufficient. Our study addresses this critical gap by analyzing trends in elderly-onset IBD over a decade, encompassing the estimation of annual frequencies and age-standardized rates of elderly-onset IBD burden for both genders, stratifying the data by geographical and sociodemographic factors. Our research highlights a notable increase in the proportion of elderly-onset IBD, constituting around 13% of all IBD cases. We observed a rising incidence in males, contrasted by a decreasing trend in females. The highest surge in incidence rates was seen in the Western Pacific region in both genders, but the highest burden was observed in America. Countries with high sociodemographic index (SDI) carried the greatest burden of elderly-onset IBD, while countries with low SDI had the least. The mortality and disability-adjusted life years (DALYs) rates trend downward in most regions. This study underscores an increasing incidence and proportion of IBD, particularly in elderly-onset IBD, particularly in males. While mortality and DALYs are decreasing in most regions, the overall burden remains highest in America and high-SDI countries. Effective public health interventions and comprehensive studies are required to tackle this mounting burden. MDPI 2023-08-06 /pmc/articles/PMC10420121/ /pubmed/37568544 http://dx.doi.org/10.3390/jcm12155142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danpanichkul, Pojsakorn
Suparan, Kanokphong
Arayakarnkul, Suchapa
Jaroenlapnopparat, Aunchalee
Polpichai, Natchaya
Fangsaard, Panisara
Kongarin, Siwanart
Srisurapanont, Karan
Sukphutanan, Banthoon
Wanchaitanawong, Wasuwit
Kanjanakot, Yatawee
Pupaibool, Jakrapun
Duangsonk, Kwanjit
Kochhar, Gursimran Singh
Wijarnpreecha, Karn
Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title_full Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title_fullStr Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title_full_unstemmed Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title_short Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
title_sort global epidemiology and burden of elderly-onset inflammatory bowel disease: a decade in review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420121/
https://www.ncbi.nlm.nih.gov/pubmed/37568544
http://dx.doi.org/10.3390/jcm12155142
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