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Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers

Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bo...

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Autores principales: Rodrigues, Fernanda Guedes, Ormanji, Milene Subtil, Pietrobom, Igor Gouveia, de Matos, Ana Cristina Carvalho, De Borst, Martin H., Heilberg, Ita Pfeferman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420207/
https://www.ncbi.nlm.nih.gov/pubmed/37568429
http://dx.doi.org/10.3390/jcm12155027
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author Rodrigues, Fernanda Guedes
Ormanji, Milene Subtil
Pietrobom, Igor Gouveia
de Matos, Ana Cristina Carvalho
De Borst, Martin H.
Heilberg, Ita Pfeferman
author_facet Rodrigues, Fernanda Guedes
Ormanji, Milene Subtil
Pietrobom, Igor Gouveia
de Matos, Ana Cristina Carvalho
De Borst, Martin H.
Heilberg, Ita Pfeferman
author_sort Rodrigues, Fernanda Guedes
collection PubMed
description Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs. Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression. Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model. Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation.
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spelling pubmed-104202072023-08-12 Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers Rodrigues, Fernanda Guedes Ormanji, Milene Subtil Pietrobom, Igor Gouveia de Matos, Ana Cristina Carvalho De Borst, Martin H. Heilberg, Ita Pfeferman J Clin Med Article Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs. Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression. Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model. Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation. MDPI 2023-07-31 /pmc/articles/PMC10420207/ /pubmed/37568429 http://dx.doi.org/10.3390/jcm12155027 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodrigues, Fernanda Guedes
Ormanji, Milene Subtil
Pietrobom, Igor Gouveia
de Matos, Ana Cristina Carvalho
De Borst, Martin H.
Heilberg, Ita Pfeferman
Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title_full Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title_fullStr Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title_full_unstemmed Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title_short Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
title_sort urinary calcium is associated with serum sclerostin among stone formers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420207/
https://www.ncbi.nlm.nih.gov/pubmed/37568429
http://dx.doi.org/10.3390/jcm12155027
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