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Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke
This study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420261/ https://www.ncbi.nlm.nih.gov/pubmed/37568307 http://dx.doi.org/10.3390/jcm12154905 |
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author | Sohn, Jong-Hee Kim, Chulho Kim, Yerim Park, So Young Lee, Sang-Hwa |
author_facet | Sohn, Jong-Hee Kim, Chulho Kim, Yerim Park, So Young Lee, Sang-Hwa |
author_sort | Sohn, Jong-Hee |
collection | PubMed |
description | This study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older than 55 years underwent routine bone densitometry within 7 days of stroke onset. OPT prescription was confirmed by reviewing medical records. We classified the patients into OPT and no OPT groups. We performed propensity score matching (PSM) to overcome the imbalance in multiple covariates between the two groups. We investigated whether OPT affected 1-year functional outcomes by multivariate analysis using a PSM cohort. Among 1307 consecutively registered acute ischemic stroke patients, 381 patients were enrolled in this study, of whom 134 (35.2%) were prescribed OPT at discharge, which was maintained for 1 year. In a multivariate analysis using a PSM cohort, the OPT group had a lower risk of dependency (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.27–0.996) and poor functional outcome at 1 year (OR, 0.24; 95% CI, 0.10–0.57). The OPT group also had increased chance of late functional improvement (OR, 6.16; 95% CI, 1.12–33.79). This study showed that OPT could reduce dependency and poor functional outcomes and increase the chance of improving functional outcomes at 3 months and 1 year after ischemic stroke onset, and these findings could be helpful for improving functional outcomes and bone health after ischemic stroke. |
format | Online Article Text |
id | pubmed-10420261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104202612023-08-12 Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke Sohn, Jong-Hee Kim, Chulho Kim, Yerim Park, So Young Lee, Sang-Hwa J Clin Med Article This study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older than 55 years underwent routine bone densitometry within 7 days of stroke onset. OPT prescription was confirmed by reviewing medical records. We classified the patients into OPT and no OPT groups. We performed propensity score matching (PSM) to overcome the imbalance in multiple covariates between the two groups. We investigated whether OPT affected 1-year functional outcomes by multivariate analysis using a PSM cohort. Among 1307 consecutively registered acute ischemic stroke patients, 381 patients were enrolled in this study, of whom 134 (35.2%) were prescribed OPT at discharge, which was maintained for 1 year. In a multivariate analysis using a PSM cohort, the OPT group had a lower risk of dependency (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.27–0.996) and poor functional outcome at 1 year (OR, 0.24; 95% CI, 0.10–0.57). The OPT group also had increased chance of late functional improvement (OR, 6.16; 95% CI, 1.12–33.79). This study showed that OPT could reduce dependency and poor functional outcomes and increase the chance of improving functional outcomes at 3 months and 1 year after ischemic stroke onset, and these findings could be helpful for improving functional outcomes and bone health after ischemic stroke. MDPI 2023-07-26 /pmc/articles/PMC10420261/ /pubmed/37568307 http://dx.doi.org/10.3390/jcm12154905 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sohn, Jong-Hee Kim, Chulho Kim, Yerim Park, So Young Lee, Sang-Hwa Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title_full | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title_fullStr | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title_full_unstemmed | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title_short | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
title_sort | impact of osteoporosis pharmacotherapy on functional outcomes after ischemic stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420261/ https://www.ncbi.nlm.nih.gov/pubmed/37568307 http://dx.doi.org/10.3390/jcm12154905 |
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