Cargando…

Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars

Helicobacter pylori infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Piasecki, Bartłomiej, Korona-Głowniak, Izabela, Kiełtyka-Dadasiewicz, Anna, Ludwiczuk, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420633/
https://www.ncbi.nlm.nih.gov/pubmed/37570659
http://dx.doi.org/10.3390/molecules28155690
_version_ 1785088770236743680
author Piasecki, Bartłomiej
Korona-Głowniak, Izabela
Kiełtyka-Dadasiewicz, Anna
Ludwiczuk, Agnieszka
author_facet Piasecki, Bartłomiej
Korona-Głowniak, Izabela
Kiełtyka-Dadasiewicz, Anna
Ludwiczuk, Agnieszka
author_sort Piasecki, Bartłomiej
collection PubMed
description Helicobacter pylori infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to which many strains are now resistant. Mentha species have been used as a natural treatment for gastrointestinal diseases throughout history and essential oils (EOs) derived from these plants show promising results as potential antimicrobial agents. In this study, EOs obtained from the leaves and flowers of five cultivars of Mentha × piperita and M. spicata were examined by GC-MS. The investigated mints are representatives of four chemotypes: the menthol chemotype (M. × piperita ‘Multimentha’ and M. × piperita ‘Swiss’), the piperitenone oxide chemotype (M. × piperita ‘Almira’), the linalool chemotype (M. × piperita ‘Granada’), and the carvone chemotype (M. spicata ‘Moroccan’). The chemical composition of EOs from mint flowers and leaves was comparable with the exception of the Swiss cultivar. Menthol was the most abundant component in the leaves while menthone was highest in flowers. The H. pylori ATCC 43504 reference strain and 10 other H. pylori clinical strains were examined for their sensitivity to the EOs in addition to their major monoterpenoid components (menthol, menthone, carvone, dihydrocarvone, linalool, 1,8-cineole, and limonene). All tested mint EOs showed inhibitory activity against both the reference H. pylori ATCC 43504 strain (MIC 15.6–31.3 mg/L) and clinical H. pylori strains (MIC(50/90) 31.3–250 mg/L/62.5–500 mg/L). Among the reference monoterpenes, menthol (MIC(50/90) 7.8/31.3 mg/L) and carvone (MIC(50/90) 31.3/62.5 mg/L) had the highest anti-H. pylori activity, which also correlated with a higher activity of EOs containing these compounds (M. × piperita ‘Swiss’ and M. spicata ‘Moroccan’). A synergistic and additive interaction between the most active EOs/compounds and antibiotics possibly points to a new plant-based anti-H. pylori treatment.
format Online
Article
Text
id pubmed-10420633
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104206332023-08-12 Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars Piasecki, Bartłomiej Korona-Głowniak, Izabela Kiełtyka-Dadasiewicz, Anna Ludwiczuk, Agnieszka Molecules Article Helicobacter pylori infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to which many strains are now resistant. Mentha species have been used as a natural treatment for gastrointestinal diseases throughout history and essential oils (EOs) derived from these plants show promising results as potential antimicrobial agents. In this study, EOs obtained from the leaves and flowers of five cultivars of Mentha × piperita and M. spicata were examined by GC-MS. The investigated mints are representatives of four chemotypes: the menthol chemotype (M. × piperita ‘Multimentha’ and M. × piperita ‘Swiss’), the piperitenone oxide chemotype (M. × piperita ‘Almira’), the linalool chemotype (M. × piperita ‘Granada’), and the carvone chemotype (M. spicata ‘Moroccan’). The chemical composition of EOs from mint flowers and leaves was comparable with the exception of the Swiss cultivar. Menthol was the most abundant component in the leaves while menthone was highest in flowers. The H. pylori ATCC 43504 reference strain and 10 other H. pylori clinical strains were examined for their sensitivity to the EOs in addition to their major monoterpenoid components (menthol, menthone, carvone, dihydrocarvone, linalool, 1,8-cineole, and limonene). All tested mint EOs showed inhibitory activity against both the reference H. pylori ATCC 43504 strain (MIC 15.6–31.3 mg/L) and clinical H. pylori strains (MIC(50/90) 31.3–250 mg/L/62.5–500 mg/L). Among the reference monoterpenes, menthol (MIC(50/90) 7.8/31.3 mg/L) and carvone (MIC(50/90) 31.3/62.5 mg/L) had the highest anti-H. pylori activity, which also correlated with a higher activity of EOs containing these compounds (M. × piperita ‘Swiss’ and M. spicata ‘Moroccan’). A synergistic and additive interaction between the most active EOs/compounds and antibiotics possibly points to a new plant-based anti-H. pylori treatment. MDPI 2023-07-27 /pmc/articles/PMC10420633/ /pubmed/37570659 http://dx.doi.org/10.3390/molecules28155690 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piasecki, Bartłomiej
Korona-Głowniak, Izabela
Kiełtyka-Dadasiewicz, Anna
Ludwiczuk, Agnieszka
Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title_full Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title_fullStr Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title_full_unstemmed Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title_short Composition and Anti-Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars
title_sort composition and anti-helicobacter pylori properties of essential oils obtained from selected mentha cultivars
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420633/
https://www.ncbi.nlm.nih.gov/pubmed/37570659
http://dx.doi.org/10.3390/molecules28155690
work_keys_str_mv AT piaseckibartłomiej compositionandantihelicobacterpyloripropertiesofessentialoilsobtainedfromselectedmenthacultivars
AT koronagłowniakizabela compositionandantihelicobacterpyloripropertiesofessentialoilsobtainedfromselectedmenthacultivars
AT kiełtykadadasiewiczanna compositionandantihelicobacterpyloripropertiesofessentialoilsobtainedfromselectedmenthacultivars
AT ludwiczukagnieszka compositionandantihelicobacterpyloripropertiesofessentialoilsobtainedfromselectedmenthacultivars