The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease

Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of several uremic toxins and their absorption into the bloodstream to worsen the renal complications. We evaluate the benefits of resistant maltodextrin (RMD) and chitosan...

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Autores principales: Anegkamol, Weerapat, Kamkang, Panumas, Hunthai, Sittiphong, Kaewwongse, Maroot, Taweevisit, Mana, Chuaypen, Natthaya, Rattanachaisit, Pakkapon, Dissayabutra, Thasinas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420640/
https://www.ncbi.nlm.nih.gov/pubmed/37571302
http://dx.doi.org/10.3390/nu15153363
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author Anegkamol, Weerapat
Kamkang, Panumas
Hunthai, Sittiphong
Kaewwongse, Maroot
Taweevisit, Mana
Chuaypen, Natthaya
Rattanachaisit, Pakkapon
Dissayabutra, Thasinas
author_facet Anegkamol, Weerapat
Kamkang, Panumas
Hunthai, Sittiphong
Kaewwongse, Maroot
Taweevisit, Mana
Chuaypen, Natthaya
Rattanachaisit, Pakkapon
Dissayabutra, Thasinas
author_sort Anegkamol, Weerapat
collection PubMed
description Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of several uremic toxins and their absorption into the bloodstream to worsen the renal complications. We evaluate the benefits of resistant maltodextrin (RMD) and chitosan oligosaccharide (COS) supplements in cell culture and CKD-induced rats. The RMD exerted a significant anti-inflammatory effect in vitro and intestinal occludin and zonula occluden-1 up-regulation in CKD rats compared with inulin and COS. While all prebiotics slightly improved gut dysbiosis, RMD remarkably promoted the relative abundance and the combined abundance of Lactobacillus, Bifidobacteria, Akkermansia, and Roseburia in CKD rats. Supplements of RMD should be advantageous in the treatment of gut leakage and microbiota dysbiosis in CKD.
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spelling pubmed-104206402023-08-12 The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease Anegkamol, Weerapat Kamkang, Panumas Hunthai, Sittiphong Kaewwongse, Maroot Taweevisit, Mana Chuaypen, Natthaya Rattanachaisit, Pakkapon Dissayabutra, Thasinas Nutrients Article Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of several uremic toxins and their absorption into the bloodstream to worsen the renal complications. We evaluate the benefits of resistant maltodextrin (RMD) and chitosan oligosaccharide (COS) supplements in cell culture and CKD-induced rats. The RMD exerted a significant anti-inflammatory effect in vitro and intestinal occludin and zonula occluden-1 up-regulation in CKD rats compared with inulin and COS. While all prebiotics slightly improved gut dysbiosis, RMD remarkably promoted the relative abundance and the combined abundance of Lactobacillus, Bifidobacteria, Akkermansia, and Roseburia in CKD rats. Supplements of RMD should be advantageous in the treatment of gut leakage and microbiota dysbiosis in CKD. MDPI 2023-07-28 /pmc/articles/PMC10420640/ /pubmed/37571302 http://dx.doi.org/10.3390/nu15153363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anegkamol, Weerapat
Kamkang, Panumas
Hunthai, Sittiphong
Kaewwongse, Maroot
Taweevisit, Mana
Chuaypen, Natthaya
Rattanachaisit, Pakkapon
Dissayabutra, Thasinas
The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title_full The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title_fullStr The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title_full_unstemmed The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title_short The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease
title_sort usefulness of resistant maltodextrin and chitosan oligosaccharide in management of gut leakage and microbiota in chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420640/
https://www.ncbi.nlm.nih.gov/pubmed/37571302
http://dx.doi.org/10.3390/nu15153363
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