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Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide

Principles of quality by design and design of experiments are acquiring more importance in the discovery and application of new drug carriers, such as solid lipid nanoparticles. In this work, an optimized synthesis of solid lipid nanoparticles loaded with Triamcinolone Acetonide is presented using a...

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Autores principales: Talarico, Luigi, Pepi, Simone, Susino, Surama, Leone, Gemma, Bonechi, Claudia, Consumi, Marco, Clemente, Ilaria, Magnani, Agnese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420805/
https://www.ncbi.nlm.nih.gov/pubmed/37570717
http://dx.doi.org/10.3390/molecules28155747
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author Talarico, Luigi
Pepi, Simone
Susino, Surama
Leone, Gemma
Bonechi, Claudia
Consumi, Marco
Clemente, Ilaria
Magnani, Agnese
author_facet Talarico, Luigi
Pepi, Simone
Susino, Surama
Leone, Gemma
Bonechi, Claudia
Consumi, Marco
Clemente, Ilaria
Magnani, Agnese
author_sort Talarico, Luigi
collection PubMed
description Principles of quality by design and design of experiments are acquiring more importance in the discovery and application of new drug carriers, such as solid lipid nanoparticles. In this work, an optimized synthesis of solid lipid nanoparticles loaded with Triamcinolone Acetonide is presented using an approach that involves Stearic Acid as a lipid, soy PC as an ionic surfactant, and Tween 80 as a nonionic surfactant. The constructed circumscribed Central Composite Design considers the lipid and nonionic surfactant quantities and the sonication amplitude in order to optimize particle size and Zeta potential, both measured by means of Dynamic Light Scattering, while the separation of unentrapped drug from the optimized Triamcinolone Acetonide-loaded solid lipid nanoparticles formulation is performed by Size Exclusion Chromatography and, subsequently, the encapsulation efficiency is determined by HPLC-DAD. The proposed optimized formulation—with the goal of maximizing Zeta potential and minimizing particle size—has shown good accordance with predicted values of Zeta potential and dimensions, as well as a high value of encapsulated Triamcinolone Acetonide. Experimental values obtained from the optimized synthesis reports a dimension of 683 ± 5 nm, which differs by 3% from the predicted value, and a Zeta potential of −38.0 ± 7.6 mV (12% difference from the predicted value).
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spelling pubmed-104208052023-08-12 Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide Talarico, Luigi Pepi, Simone Susino, Surama Leone, Gemma Bonechi, Claudia Consumi, Marco Clemente, Ilaria Magnani, Agnese Molecules Article Principles of quality by design and design of experiments are acquiring more importance in the discovery and application of new drug carriers, such as solid lipid nanoparticles. In this work, an optimized synthesis of solid lipid nanoparticles loaded with Triamcinolone Acetonide is presented using an approach that involves Stearic Acid as a lipid, soy PC as an ionic surfactant, and Tween 80 as a nonionic surfactant. The constructed circumscribed Central Composite Design considers the lipid and nonionic surfactant quantities and the sonication amplitude in order to optimize particle size and Zeta potential, both measured by means of Dynamic Light Scattering, while the separation of unentrapped drug from the optimized Triamcinolone Acetonide-loaded solid lipid nanoparticles formulation is performed by Size Exclusion Chromatography and, subsequently, the encapsulation efficiency is determined by HPLC-DAD. The proposed optimized formulation—with the goal of maximizing Zeta potential and minimizing particle size—has shown good accordance with predicted values of Zeta potential and dimensions, as well as a high value of encapsulated Triamcinolone Acetonide. Experimental values obtained from the optimized synthesis reports a dimension of 683 ± 5 nm, which differs by 3% from the predicted value, and a Zeta potential of −38.0 ± 7.6 mV (12% difference from the predicted value). MDPI 2023-07-29 /pmc/articles/PMC10420805/ /pubmed/37570717 http://dx.doi.org/10.3390/molecules28155747 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Talarico, Luigi
Pepi, Simone
Susino, Surama
Leone, Gemma
Bonechi, Claudia
Consumi, Marco
Clemente, Ilaria
Magnani, Agnese
Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title_full Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title_fullStr Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title_full_unstemmed Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title_short Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide
title_sort design and optimization of solid lipid nanoparticles loaded with triamcinolone acetonide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420805/
https://www.ncbi.nlm.nih.gov/pubmed/37570717
http://dx.doi.org/10.3390/molecules28155747
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