Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners

The aberrant expansion of GGGGCC hexanucleotide repeats within the first intron of the C9orf72 gene represent the predominant genetic etiology underlying amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). The transcribed r(GGGGCC)(n) RNA repeats form RNA foci, which recruit RNA...

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Detalles Bibliográficos
Autores principales: Liu, Xiaole, Zhao, Xinyue, He, Jinhan, Wang, Sishi, Shen, Xinfei, Liu, Qingfeng, Wang, Shenlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420822/
https://www.ncbi.nlm.nih.gov/pubmed/37570771
http://dx.doi.org/10.3390/molecules28155801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420822/
https://www.ncbi.nlm.nih.gov/pubmed/37570771
http://dx.doi.org/10.3390/molecules28155801

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