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Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study

The estimated glomerular filtration rate (eGFR) is a comprehensive index that is widely used to assess renal function. Although studies have confirmed a correlation between eGFR and dietary vitamin C, the impact of varying levels of vitamin C on eGFR remains unclear. Additionally, the interaction be...

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Autores principales: Lin, Zheng‐yang, Liang, Yong‐yi, Wang, Ru, Hu, Biao, He, Wen‐ju, Li, Jun‐kui, Ding, Zi‐ang, Lin, Zhuo‐yuan, Zhang, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420853/
https://www.ncbi.nlm.nih.gov/pubmed/37576036
http://dx.doi.org/10.1002/fsn3.3456
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author Lin, Zheng‐yang
Liang, Yong‐yi
Wang, Ru
Hu, Biao
He, Wen‐ju
Li, Jun‐kui
Ding, Zi‐ang
Lin, Zhuo‐yuan
Zhang, Shi
author_facet Lin, Zheng‐yang
Liang, Yong‐yi
Wang, Ru
Hu, Biao
He, Wen‐ju
Li, Jun‐kui
Ding, Zi‐ang
Lin, Zhuo‐yuan
Zhang, Shi
author_sort Lin, Zheng‐yang
collection PubMed
description The estimated glomerular filtration rate (eGFR) is a comprehensive index that is widely used to assess renal function. Although studies have confirmed a correlation between eGFR and dietary vitamin C, the impact of varying levels of vitamin C on eGFR remains unclear. Additionally, the interaction between dietary magnesium intake and vitamin C concentration on eGFR is not well understood. As such, the objective of this study was to investigate the relationship between dietary magnesium intake and vitamin C in relation to eGFR. This study analyzed the data of consecutive NHANES from 2005 to 2018. We included 17,633 participants aged 20 or older and used multiple linear regression analysis to evaluate the relationship between dietary vitamin C and eGFR. Dietary Mg intake from experimental data was dichotomized into a low dietary Mg intake group (≤254 mg/day) and a normal dietary Mg intake group (>254 mg/day). To evaluate the impact of dietary magnesium intake on eGFR, a multivariable linear regression was conducted utilizing an interaction test between dietary vitamin C and eGFR. We discovered a positive association between dietary vitamin C content and eGFR. The relationship between dietary vitamin C levels and eGFR differed between individuals with low Mg intake and those with normal Mg intake (β: 2.96 95% CI:1.63 ~ 4.29 vs. β: 1.05 95% CI: −0.15 to 2.25), and the positive association of high dietary vitamin C content with eGFR was stronger in the low Mg intake group. Furthermore, we observed that dietary magnesium intake significantly altered the positive association between dietary vitamin C and eGFR (interaction value of 0.020). Our experimental study revealed that the interaction between dietary magnesium and dietary vitamin C can significantly impact eGFR. This finding carries significant implications for the treatment of diseases resulting from abnormal eGFR, as well as the selection of clinically relevant drugs.
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spelling pubmed-104208532023-08-12 Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study Lin, Zheng‐yang Liang, Yong‐yi Wang, Ru Hu, Biao He, Wen‐ju Li, Jun‐kui Ding, Zi‐ang Lin, Zhuo‐yuan Zhang, Shi Food Sci Nutr Original Articles The estimated glomerular filtration rate (eGFR) is a comprehensive index that is widely used to assess renal function. Although studies have confirmed a correlation between eGFR and dietary vitamin C, the impact of varying levels of vitamin C on eGFR remains unclear. Additionally, the interaction between dietary magnesium intake and vitamin C concentration on eGFR is not well understood. As such, the objective of this study was to investigate the relationship between dietary magnesium intake and vitamin C in relation to eGFR. This study analyzed the data of consecutive NHANES from 2005 to 2018. We included 17,633 participants aged 20 or older and used multiple linear regression analysis to evaluate the relationship between dietary vitamin C and eGFR. Dietary Mg intake from experimental data was dichotomized into a low dietary Mg intake group (≤254 mg/day) and a normal dietary Mg intake group (>254 mg/day). To evaluate the impact of dietary magnesium intake on eGFR, a multivariable linear regression was conducted utilizing an interaction test between dietary vitamin C and eGFR. We discovered a positive association between dietary vitamin C content and eGFR. The relationship between dietary vitamin C levels and eGFR differed between individuals with low Mg intake and those with normal Mg intake (β: 2.96 95% CI:1.63 ~ 4.29 vs. β: 1.05 95% CI: −0.15 to 2.25), and the positive association of high dietary vitamin C content with eGFR was stronger in the low Mg intake group. Furthermore, we observed that dietary magnesium intake significantly altered the positive association between dietary vitamin C and eGFR (interaction value of 0.020). Our experimental study revealed that the interaction between dietary magnesium and dietary vitamin C can significantly impact eGFR. This finding carries significant implications for the treatment of diseases resulting from abnormal eGFR, as well as the selection of clinically relevant drugs. John Wiley and Sons Inc. 2023-06-01 /pmc/articles/PMC10420853/ /pubmed/37576036 http://dx.doi.org/10.1002/fsn3.3456 Text en © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lin, Zheng‐yang
Liang, Yong‐yi
Wang, Ru
Hu, Biao
He, Wen‐ju
Li, Jun‐kui
Ding, Zi‐ang
Lin, Zhuo‐yuan
Zhang, Shi
Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title_full Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title_fullStr Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title_full_unstemmed Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title_short Dietary magnesium is able to influence the relationship between vitamin C and estimated glomerular filtration rate: A cross‐sectional study
title_sort dietary magnesium is able to influence the relationship between vitamin c and estimated glomerular filtration rate: a cross‐sectional study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420853/
https://www.ncbi.nlm.nih.gov/pubmed/37576036
http://dx.doi.org/10.1002/fsn3.3456
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