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Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men

High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA level...

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Autores principales: Lin, Hui-Yi, Zhu, Xiaodan, Aucoin, Alise J., Fu, Qiufan, Park, Jong Y., Tseng, Tung-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420876/
https://www.ncbi.nlm.nih.gov/pubmed/37571238
http://dx.doi.org/10.3390/nu15153298
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author Lin, Hui-Yi
Zhu, Xiaodan
Aucoin, Alise J.
Fu, Qiufan
Park, Jong Y.
Tseng, Tung-Sung
author_facet Lin, Hui-Yi
Zhu, Xiaodan
Aucoin, Alise J.
Fu, Qiufan
Park, Jong Y.
Tseng, Tung-Sung
author_sort Lin, Hui-Yi
collection PubMed
description High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA levels for United States (US) men. We assessed 7398 men using the 2003–2010 US population-based National Health and Nutrition Examination Survey (NHANES). The PSA levels were categorized into three groups: Normal, borderline, and elevated levels. We performed analyses for middle-aged and older groups aged 40–64.9 and ≥65, respectively. The weighted multinomial regressions were performed to evaluate antioxidants associated with the PSA status. For results, 0.3% and 3.4% of middle-aged and older men, respectively, had elevated PSA (>10 ng/mL). Men with a higher serum albumin level had a lower risk of an elevated PSA, adjusting for age. The magnitude of albumin’s impact on PSA is larger in middle-aged men than in older men (OR of elevated PSA = 0.82 and 0.90, respectively, interaction p = 0.002). Other antioxidants are not associated with PSA. Our findings support men with low serum albumin tend to have an elevated PSA level, so related interventions can be considered to decrease PSA for maintaining prostate health.
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spelling pubmed-104208762023-08-12 Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men Lin, Hui-Yi Zhu, Xiaodan Aucoin, Alise J. Fu, Qiufan Park, Jong Y. Tseng, Tung-Sung Nutrients Article High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA levels for United States (US) men. We assessed 7398 men using the 2003–2010 US population-based National Health and Nutrition Examination Survey (NHANES). The PSA levels were categorized into three groups: Normal, borderline, and elevated levels. We performed analyses for middle-aged and older groups aged 40–64.9 and ≥65, respectively. The weighted multinomial regressions were performed to evaluate antioxidants associated with the PSA status. For results, 0.3% and 3.4% of middle-aged and older men, respectively, had elevated PSA (>10 ng/mL). Men with a higher serum albumin level had a lower risk of an elevated PSA, adjusting for age. The magnitude of albumin’s impact on PSA is larger in middle-aged men than in older men (OR of elevated PSA = 0.82 and 0.90, respectively, interaction p = 0.002). Other antioxidants are not associated with PSA. Our findings support men with low serum albumin tend to have an elevated PSA level, so related interventions can be considered to decrease PSA for maintaining prostate health. MDPI 2023-07-25 /pmc/articles/PMC10420876/ /pubmed/37571238 http://dx.doi.org/10.3390/nu15153298 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Hui-Yi
Zhu, Xiaodan
Aucoin, Alise J.
Fu, Qiufan
Park, Jong Y.
Tseng, Tung-Sung
Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title_full Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title_fullStr Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title_full_unstemmed Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title_short Dietary and Serum Antioxidants Associated with Prostate-Specific Antigen for Middle-Aged and Older Men
title_sort dietary and serum antioxidants associated with prostate-specific antigen for middle-aged and older men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420876/
https://www.ncbi.nlm.nih.gov/pubmed/37571238
http://dx.doi.org/10.3390/nu15153298
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