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Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study
This study aimed to investigate the association between dietary acid load (DAL) and multiple sclerosis (MS), through the potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. In a hospital-based case–control study of 109 patients with MS and 130 healthy individuals, a va...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420939/ https://www.ncbi.nlm.nih.gov/pubmed/37571248 http://dx.doi.org/10.3390/nu15153311 |
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author | Saeedirad, Zahra Ariyanfar, Shadi Noormohammadi, Morvarid Ghorbani, Zeinab Naser Moghadasi, Abdorreza Shahemi, Sahar Ghanaatgar, Milad Rezaeimanesh, Nasim Hekmatdoost, Azita Ghaemi, Amir Razeghi Jahromi, Soodeh |
author_facet | Saeedirad, Zahra Ariyanfar, Shadi Noormohammadi, Morvarid Ghorbani, Zeinab Naser Moghadasi, Abdorreza Shahemi, Sahar Ghanaatgar, Milad Rezaeimanesh, Nasim Hekmatdoost, Azita Ghaemi, Amir Razeghi Jahromi, Soodeh |
author_sort | Saeedirad, Zahra |
collection | PubMed |
description | This study aimed to investigate the association between dietary acid load (DAL) and multiple sclerosis (MS), through the potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. In a hospital-based case–control study of 109 patients with MS and 130 healthy individuals, a validated 168-item semi-quantitative food frequency questionnaire and a logistic regression model were used to evaluate the association between the DAL and MS. After adjusting for age (years), gender (male/female), body mass index (Kg/m(2)), and total calories (Kcal), the MS odds were 92% lower for those in the highest tertile of total plant-based protein (OR: 0.08, 95%CI: 0.03, 0.23; p-value < 0.001) and about four times higher for those in the highest tertile of the PRAL (OR: 4.16, 95%CI: 1.94, 8.91; p-value < 0.001) and NEAP scores (OR: 3.57, 95%CI: 1.69, 7.53; p-value < 0.001), compared to those in the lowest tertile. After further adjusting for sodium, saturated fatty acid, and fiber intake, the results remained significant for total plant-based protein intake (OR: 0.07, 95%CI: 0.01, 0.38; p-value = 0.002). In conclusion, a higher NEAP or PRAL score may be associated with increased odds of MS, while a higher intake of plant-based protein instead of animal-based protein may be protective. |
format | Online Article Text |
id | pubmed-10420939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104209392023-08-12 Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study Saeedirad, Zahra Ariyanfar, Shadi Noormohammadi, Morvarid Ghorbani, Zeinab Naser Moghadasi, Abdorreza Shahemi, Sahar Ghanaatgar, Milad Rezaeimanesh, Nasim Hekmatdoost, Azita Ghaemi, Amir Razeghi Jahromi, Soodeh Nutrients Article This study aimed to investigate the association between dietary acid load (DAL) and multiple sclerosis (MS), through the potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. In a hospital-based case–control study of 109 patients with MS and 130 healthy individuals, a validated 168-item semi-quantitative food frequency questionnaire and a logistic regression model were used to evaluate the association between the DAL and MS. After adjusting for age (years), gender (male/female), body mass index (Kg/m(2)), and total calories (Kcal), the MS odds were 92% lower for those in the highest tertile of total plant-based protein (OR: 0.08, 95%CI: 0.03, 0.23; p-value < 0.001) and about four times higher for those in the highest tertile of the PRAL (OR: 4.16, 95%CI: 1.94, 8.91; p-value < 0.001) and NEAP scores (OR: 3.57, 95%CI: 1.69, 7.53; p-value < 0.001), compared to those in the lowest tertile. After further adjusting for sodium, saturated fatty acid, and fiber intake, the results remained significant for total plant-based protein intake (OR: 0.07, 95%CI: 0.01, 0.38; p-value = 0.002). In conclusion, a higher NEAP or PRAL score may be associated with increased odds of MS, while a higher intake of plant-based protein instead of animal-based protein may be protective. MDPI 2023-07-26 /pmc/articles/PMC10420939/ /pubmed/37571248 http://dx.doi.org/10.3390/nu15153311 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Saeedirad, Zahra Ariyanfar, Shadi Noormohammadi, Morvarid Ghorbani, Zeinab Naser Moghadasi, Abdorreza Shahemi, Sahar Ghanaatgar, Milad Rezaeimanesh, Nasim Hekmatdoost, Azita Ghaemi, Amir Razeghi Jahromi, Soodeh Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title | Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title_full | Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title_fullStr | Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title_full_unstemmed | Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title_short | Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case–Control Study |
title_sort | higher dietary acid load might be a potent derivative factor for multiple sclerosis: the results from a case–control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420939/ https://www.ncbi.nlm.nih.gov/pubmed/37571248 http://dx.doi.org/10.3390/nu15153311 |
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