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Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial

Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested...

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Autores principales: Schmidt, Kelsey A., Mokhtari, Pari, Holzhausen, Elizabeth A., Alderete, Tanya L., Allayee, Hooman, Nayak, Krishna S., Sinatra, Frank R., Pickering, Trevor A., Mack, Wendy, Kohli, Rohit, Goran, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420969/
https://www.ncbi.nlm.nih.gov/pubmed/37571275
http://dx.doi.org/10.3390/nu15153338
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author Schmidt, Kelsey A.
Mokhtari, Pari
Holzhausen, Elizabeth A.
Alderete, Tanya L.
Allayee, Hooman
Nayak, Krishna S.
Sinatra, Frank R.
Pickering, Trevor A.
Mack, Wendy
Kohli, Rohit
Goran, Michael I.
author_facet Schmidt, Kelsey A.
Mokhtari, Pari
Holzhausen, Elizabeth A.
Alderete, Tanya L.
Allayee, Hooman
Nayak, Krishna S.
Sinatra, Frank R.
Pickering, Trevor A.
Mack, Wendy
Kohli, Rohit
Goran, Michael I.
author_sort Schmidt, Kelsey A.
collection PubMed
description Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI ≥ 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of ≤10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF- [Formula: see text]). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (p(all) > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF- [Formula: see text] (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity.
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spelling pubmed-104209692023-08-12 Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial Schmidt, Kelsey A. Mokhtari, Pari Holzhausen, Elizabeth A. Alderete, Tanya L. Allayee, Hooman Nayak, Krishna S. Sinatra, Frank R. Pickering, Trevor A. Mack, Wendy Kohli, Rohit Goran, Michael I. Nutrients Article Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI ≥ 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of ≤10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF- [Formula: see text]). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (p(all) > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF- [Formula: see text] (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity. MDPI 2023-07-27 /pmc/articles/PMC10420969/ /pubmed/37571275 http://dx.doi.org/10.3390/nu15153338 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schmidt, Kelsey A.
Mokhtari, Pari
Holzhausen, Elizabeth A.
Alderete, Tanya L.
Allayee, Hooman
Nayak, Krishna S.
Sinatra, Frank R.
Pickering, Trevor A.
Mack, Wendy
Kohli, Rohit
Goran, Michael I.
Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title_full Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title_fullStr Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title_full_unstemmed Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title_short Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial
title_sort effects of dietary sugar reduction on biomarkers of cardiometabolic health in latino youth: secondary analyses from a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420969/
https://www.ncbi.nlm.nih.gov/pubmed/37571275
http://dx.doi.org/10.3390/nu15153338
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