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Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 m...

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Autores principales: Abdelgawad, Fatma Alzahra M., El-Hawary, Seham S., Abd El-Kader, Essam M., Alshehri, Saad Ali, Rabeh, Mohamed Abdelaaty, El-Mosallamy, Aliaa E. M. K., El Raey, Mohamed A., El Gedaily, Rania A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420985/
https://www.ncbi.nlm.nih.gov/pubmed/37570967
http://dx.doi.org/10.3390/plants12152813
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author Abdelgawad, Fatma Alzahra M.
El-Hawary, Seham S.
Abd El-Kader, Essam M.
Alshehri, Saad Ali
Rabeh, Mohamed Abdelaaty
El-Mosallamy, Aliaa E. M. K.
El Raey, Mohamed A.
El Gedaily, Rania A.
author_facet Abdelgawad, Fatma Alzahra M.
El-Hawary, Seham S.
Abd El-Kader, Essam M.
Alshehri, Saad Ali
Rabeh, Mohamed Abdelaaty
El-Mosallamy, Aliaa E. M. K.
El Raey, Mohamed A.
El Gedaily, Rania A.
author_sort Abdelgawad, Fatma Alzahra M.
collection PubMed
description Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC(50)) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC(50)) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica. More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
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spelling pubmed-104209852023-08-12 Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E Abdelgawad, Fatma Alzahra M. El-Hawary, Seham S. Abd El-Kader, Essam M. Alshehri, Saad Ali Rabeh, Mohamed Abdelaaty El-Mosallamy, Aliaa E. M. K. El Raey, Mohamed A. El Gedaily, Rania A. Plants (Basel) Article Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC(50)) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC(50)) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica. More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications. MDPI 2023-07-29 /pmc/articles/PMC10420985/ /pubmed/37570967 http://dx.doi.org/10.3390/plants12152813 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdelgawad, Fatma Alzahra M.
El-Hawary, Seham S.
Abd El-Kader, Essam M.
Alshehri, Saad Ali
Rabeh, Mohamed Abdelaaty
El-Mosallamy, Aliaa E. M. K.
El Raey, Mohamed A.
El Gedaily, Rania A.
Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title_full Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title_fullStr Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title_full_unstemmed Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title_short Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
title_sort phytochemical profiling and antiviral activity of green sustainable nanoparticles derived from maesa indica (roxb.) sweet against human coronavirus 229e
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420985/
https://www.ncbi.nlm.nih.gov/pubmed/37570967
http://dx.doi.org/10.3390/plants12152813
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