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Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue
Multiple sclerosis (MS) is a neuroinflammatory disease characterized by loss of myelin (demyelination) and, to a certain extent, subsequent myelin repair (remyelination). To better understand the pathomechanisms underlying de- and remyelination and to monitor the efficacy of treatments aimed at rege...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421026/ https://www.ncbi.nlm.nih.gov/pubmed/37566661 http://dx.doi.org/10.1126/sciadv.adi0611 |
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author | Baadsvik, Emily Louise Weiger, Markus Froidevaux, Romain Faigle, Wolfgang Ineichen, Benjamin V. Pruessmann, Klaas P. |
author_facet | Baadsvik, Emily Louise Weiger, Markus Froidevaux, Romain Faigle, Wolfgang Ineichen, Benjamin V. Pruessmann, Klaas P. |
author_sort | Baadsvik, Emily Louise |
collection | PubMed |
description | Multiple sclerosis (MS) is a neuroinflammatory disease characterized by loss of myelin (demyelination) and, to a certain extent, subsequent myelin repair (remyelination). To better understand the pathomechanisms underlying de- and remyelination and to monitor the efficacy of treatments aimed at regenerating myelin, techniques offering noninvasive visualizations of myelin are warranted. Magnetic resonance (MR) imaging has long been at the forefront of efforts to visualize myelin, but it has only recently become feasible to access the rapidly decaying resonance signals stemming from the myelin lipid-protein bilayer itself. Here, we show that direct MR mapping of the bilayer yields highly specific myelin maps in brain tissue from patients with MS. Furthermore, examination of the bilayer signal behavior is found to reveal pathological alterations in normal-appearing white and gray matter. These results indicate promise for in vivo implementations of the myelin bilayer mapping technique, with prospective applications in basic research, diagnostics, disease monitoring, and drug development. |
format | Online Article Text |
id | pubmed-10421026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104210262023-08-12 Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue Baadsvik, Emily Louise Weiger, Markus Froidevaux, Romain Faigle, Wolfgang Ineichen, Benjamin V. Pruessmann, Klaas P. Sci Adv Physical and Materials Sciences Multiple sclerosis (MS) is a neuroinflammatory disease characterized by loss of myelin (demyelination) and, to a certain extent, subsequent myelin repair (remyelination). To better understand the pathomechanisms underlying de- and remyelination and to monitor the efficacy of treatments aimed at regenerating myelin, techniques offering noninvasive visualizations of myelin are warranted. Magnetic resonance (MR) imaging has long been at the forefront of efforts to visualize myelin, but it has only recently become feasible to access the rapidly decaying resonance signals stemming from the myelin lipid-protein bilayer itself. Here, we show that direct MR mapping of the bilayer yields highly specific myelin maps in brain tissue from patients with MS. Furthermore, examination of the bilayer signal behavior is found to reveal pathological alterations in normal-appearing white and gray matter. These results indicate promise for in vivo implementations of the myelin bilayer mapping technique, with prospective applications in basic research, diagnostics, disease monitoring, and drug development. American Association for the Advancement of Science 2023-08-11 /pmc/articles/PMC10421026/ /pubmed/37566661 http://dx.doi.org/10.1126/sciadv.adi0611 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Baadsvik, Emily Louise Weiger, Markus Froidevaux, Romain Faigle, Wolfgang Ineichen, Benjamin V. Pruessmann, Klaas P. Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title | Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title_full | Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title_fullStr | Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title_full_unstemmed | Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title_short | Quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
title_sort | quantitative magnetic resonance mapping of the myelin bilayer reflects pathology in multiple sclerosis brain tissue |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421026/ https://www.ncbi.nlm.nih.gov/pubmed/37566661 http://dx.doi.org/10.1126/sciadv.adi0611 |
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