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Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort

Vitamin D is a fat-soluble vitamin that plays a key role in bone metabolism, particularly concerning the regulation of calcium and phosphate homeostasis. Cardiovascular disease (CVD) is the main cause of morbidity and mortality in Western countries. Knowledge of the role of vitamin D in CVD arose fr...

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Autores principales: Pirrotta, Filippo, Cavati, Guido, Mingiano, Christian, Merlotti, Daniela, Nuti, Ranuccio, Gennari, Luigi, Palazzuoli, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421091/
https://www.ncbi.nlm.nih.gov/pubmed/37571241
http://dx.doi.org/10.3390/nu15153303
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author Pirrotta, Filippo
Cavati, Guido
Mingiano, Christian
Merlotti, Daniela
Nuti, Ranuccio
Gennari, Luigi
Palazzuoli, Alberto
author_facet Pirrotta, Filippo
Cavati, Guido
Mingiano, Christian
Merlotti, Daniela
Nuti, Ranuccio
Gennari, Luigi
Palazzuoli, Alberto
author_sort Pirrotta, Filippo
collection PubMed
description Vitamin D is a fat-soluble vitamin that plays a key role in bone metabolism, particularly concerning the regulation of calcium and phosphate homeostasis. Cardiovascular disease (CVD) is the main cause of morbidity and mortality in Western countries. Knowledge of the role of vitamin D in CVD arose from evidence of the vitamin D receptor (VDR) inside the cardiovascular system. In this retrospective analysis, we investigated the relationships between vitamin D status and hospitalization for heart failure (HF), overall mortality and cardiovascular mortality. Between 2004 and 2009, age-stratified, random sampling of elderly men and postmenopausal women in the primary care registers of Siena residents was performed. In total, 174 males (mean ± SD, 65.9 ± 6 years) and 975 females (62.5 ± 6 years) were enrolled in the study. We investigated the association between 25OHD status and hospitalization for HF or causes of mortality. A total of 51 subjects (12 males and 39 females) had been hospitalized for acute HF. At the end of the survey, 931 individuals were alive, while 187 had died (43 males and 144 females). A greater proportion of deceased patients showed low 25OHD (particularly patients with levels below 20 ng/mL). A similar trend was observed concerning the prevalence of patients with 25OHD levels below 20 ng/mL who died from stroke (RR = 2.15; 95% CIs 0.98–4.69; p = 0.06). Low 25OHD levels may be predictive of cardiovascular mortality. Whether vitamin deficiency represents a primitive cause or is a simple bystander in increased cardiovascular mortality should be further investigated in prospective large cohort studies specifically designed to assess CVD risk, including a detailed assessment of cardiac dysfunction and the characterization of atherosclerotic lesions.
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spelling pubmed-104210912023-08-12 Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort Pirrotta, Filippo Cavati, Guido Mingiano, Christian Merlotti, Daniela Nuti, Ranuccio Gennari, Luigi Palazzuoli, Alberto Nutrients Article Vitamin D is a fat-soluble vitamin that plays a key role in bone metabolism, particularly concerning the regulation of calcium and phosphate homeostasis. Cardiovascular disease (CVD) is the main cause of morbidity and mortality in Western countries. Knowledge of the role of vitamin D in CVD arose from evidence of the vitamin D receptor (VDR) inside the cardiovascular system. In this retrospective analysis, we investigated the relationships between vitamin D status and hospitalization for heart failure (HF), overall mortality and cardiovascular mortality. Between 2004 and 2009, age-stratified, random sampling of elderly men and postmenopausal women in the primary care registers of Siena residents was performed. In total, 174 males (mean ± SD, 65.9 ± 6 years) and 975 females (62.5 ± 6 years) were enrolled in the study. We investigated the association between 25OHD status and hospitalization for HF or causes of mortality. A total of 51 subjects (12 males and 39 females) had been hospitalized for acute HF. At the end of the survey, 931 individuals were alive, while 187 had died (43 males and 144 females). A greater proportion of deceased patients showed low 25OHD (particularly patients with levels below 20 ng/mL). A similar trend was observed concerning the prevalence of patients with 25OHD levels below 20 ng/mL who died from stroke (RR = 2.15; 95% CIs 0.98–4.69; p = 0.06). Low 25OHD levels may be predictive of cardiovascular mortality. Whether vitamin deficiency represents a primitive cause or is a simple bystander in increased cardiovascular mortality should be further investigated in prospective large cohort studies specifically designed to assess CVD risk, including a detailed assessment of cardiac dysfunction and the characterization of atherosclerotic lesions. MDPI 2023-07-25 /pmc/articles/PMC10421091/ /pubmed/37571241 http://dx.doi.org/10.3390/nu15153303 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirrotta, Filippo
Cavati, Guido
Mingiano, Christian
Merlotti, Daniela
Nuti, Ranuccio
Gennari, Luigi
Palazzuoli, Alberto
Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title_full Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title_fullStr Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title_full_unstemmed Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title_short Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis “Siena Osteoporosis” Cohort
title_sort vitamin d deficiency and cardiovascular mortality: retrospective analysis “siena osteoporosis” cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421091/
https://www.ncbi.nlm.nih.gov/pubmed/37571241
http://dx.doi.org/10.3390/nu15153303
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