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Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights

Bariatric surgery (BS) can have negative effects on bone health. Bone microarchitecture quality evaluation using the trabecular bone score (TBS) has not been described in patients after sleeve gastrectomy (SG). To test the hypothesis that the TBS is clinically useful for this population, we evaluate...

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Autores principales: Stokar, Joshua, Ben-Porat, Tair, Kaluti, Donia, Abu-Gazala, Mahmud, Weiss, Ram, Mintz, Yoav, Elazari, Ram, Szalat, Auryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421136/
https://www.ncbi.nlm.nih.gov/pubmed/37571418
http://dx.doi.org/10.3390/nu15153481
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author Stokar, Joshua
Ben-Porat, Tair
Kaluti, Donia
Abu-Gazala, Mahmud
Weiss, Ram
Mintz, Yoav
Elazari, Ram
Szalat, Auryan
author_facet Stokar, Joshua
Ben-Porat, Tair
Kaluti, Donia
Abu-Gazala, Mahmud
Weiss, Ram
Mintz, Yoav
Elazari, Ram
Szalat, Auryan
author_sort Stokar, Joshua
collection PubMed
description Bariatric surgery (BS) can have negative effects on bone health. Bone microarchitecture quality evaluation using the trabecular bone score (TBS) has not been described in patients after sleeve gastrectomy (SG). To test the hypothesis that the TBS is clinically useful for this population, we evaluated changes in bone mineral density (BMD) and the TBS in a longitudinal cohort study following SG. The measurements before surgery and after 12 and 24 postoperative months were as follows: weight, height, BMI, waist circumference (WC), BMD and TBS. The results at baseline showed the following: a mean BMI of 43 ± 0.56, TBS of 1.25 ± 0.02, lumbar spine BMD T-score of −0.4 ± 0.93, TBS T-score of −2.30 ± 0.21, significantly lower than BMD-T-score, and associated with a BMD-T-TBS-T gap (T-gap) of −2.05 ± 1.26 (−0.24 ± 0.13). One year after surgery, the TBS had significantly improved (+12.12% ± 1.5), leading to a T-gap of −0.296 ± 0.14, which remained stable at 2 years post-surgery. A correlation analysis revealed a significant negative correlation between the T-gap and WC (r = −0.43 p = 0.004). Our interpretation is that abdominal fat may interfere with image acquisition via increased tissue thickness, leading to a false low TBS at baseline. In conclusion, TBS should be interpreted with caution in patients with obesity and elevated WC. Additionally, we show that after SG, the LS microarchitecture measured using the TBS is partially degraded in up to 25% of patients. Further studies are warranted to assess hip bone microarchitecture changes after bariatric surgery.
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spelling pubmed-104211362023-08-12 Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights Stokar, Joshua Ben-Porat, Tair Kaluti, Donia Abu-Gazala, Mahmud Weiss, Ram Mintz, Yoav Elazari, Ram Szalat, Auryan Nutrients Brief Report Bariatric surgery (BS) can have negative effects on bone health. Bone microarchitecture quality evaluation using the trabecular bone score (TBS) has not been described in patients after sleeve gastrectomy (SG). To test the hypothesis that the TBS is clinically useful for this population, we evaluated changes in bone mineral density (BMD) and the TBS in a longitudinal cohort study following SG. The measurements before surgery and after 12 and 24 postoperative months were as follows: weight, height, BMI, waist circumference (WC), BMD and TBS. The results at baseline showed the following: a mean BMI of 43 ± 0.56, TBS of 1.25 ± 0.02, lumbar spine BMD T-score of −0.4 ± 0.93, TBS T-score of −2.30 ± 0.21, significantly lower than BMD-T-score, and associated with a BMD-T-TBS-T gap (T-gap) of −2.05 ± 1.26 (−0.24 ± 0.13). One year after surgery, the TBS had significantly improved (+12.12% ± 1.5), leading to a T-gap of −0.296 ± 0.14, which remained stable at 2 years post-surgery. A correlation analysis revealed a significant negative correlation between the T-gap and WC (r = −0.43 p = 0.004). Our interpretation is that abdominal fat may interfere with image acquisition via increased tissue thickness, leading to a false low TBS at baseline. In conclusion, TBS should be interpreted with caution in patients with obesity and elevated WC. Additionally, we show that after SG, the LS microarchitecture measured using the TBS is partially degraded in up to 25% of patients. Further studies are warranted to assess hip bone microarchitecture changes after bariatric surgery. MDPI 2023-08-07 /pmc/articles/PMC10421136/ /pubmed/37571418 http://dx.doi.org/10.3390/nu15153481 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Stokar, Joshua
Ben-Porat, Tair
Kaluti, Donia
Abu-Gazala, Mahmud
Weiss, Ram
Mintz, Yoav
Elazari, Ram
Szalat, Auryan
Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title_full Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title_fullStr Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title_full_unstemmed Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title_short Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights
title_sort trabecular bone score preceding and during a 2-year follow-up after sleeve gastrectomy: pitfalls and new insights
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421136/
https://www.ncbi.nlm.nih.gov/pubmed/37571418
http://dx.doi.org/10.3390/nu15153481
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